Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 52276..52805 Replicon plasmid pRS1931m
Accession NZ_CP093536
Organism Ralstonia pseudosolanacearum strain SL1931

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MNY32_RS17810 Protein ID WP_237177642.1
Coordinates 52578..52805 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MNY32_RS17805 Protein ID WP_016722339.1
Coordinates 52276..52581 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY32_RS17775 (MNY32_17775) 47453..47737 - 285 WP_011003391.1 hypothetical protein -
MNY32_RS17780 (MNY32_17780) 48106..48257 + 152 Protein_44 IS5/IS1182 family transposase -
MNY32_RS17785 (MNY32_17785) 49274..49609 + 336 WP_241788079.1 hypothetical protein -
MNY32_RS17790 (MNY32_17790) 50004..50243 + 240 WP_089191147.1 hypothetical protein -
MNY32_RS17795 (MNY32_17795) 50293..50580 - 288 WP_043898169.1 barstar family protein -
MNY32_RS17800 (MNY32_17800) 50750..52063 - 1314 WP_064478230.1 MFS family transporter -
MNY32_RS17805 (MNY32_17805) 52276..52581 - 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
MNY32_RS17810 (MNY32_17810) 52578..52805 - 228 WP_237177642.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNY32_RS17815 (MNY32_17815) 52960..54159 - 1200 WP_089190958.1 MFS transporter -
MNY32_RS17820 (MNY32_17820) 54287..55108 - 822 WP_089190959.1 GntR family transcriptional regulator -
MNY32_RS17825 (MNY32_17825) 55286..55837 - 552 WP_011003399.1 helix-turn-helix domain-containing protein -
MNY32_RS17830 (MNY32_17830) 55970..56569 + 600 WP_064478235.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - motA / cheW / cheB / cheY / adeG / htpB / acrB / fliI / fliG / fliM / flgG / flgC / cyaB 1..2075606 2075606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-69)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8567.83 Da        Isoelectric Point: 6.7166

>T238840 WP_237177642.1 NZ_CP093536:c52805-52578 [Ralstonia pseudosolanacearum]
VRIDRLQMGHPGDMKAVRDGIRELRIDHGPGDRLYFVRHGVVLIVLLCGGDKSTQETDIRRAIDLSRRLDVDDME

Download         Length: 228 bp

>T238840 NZ_LR890504:28345-28503 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT238840 WP_016722339.1 NZ_CP093536:c52581-52276 [Ralstonia pseudosolanacearum]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT238840 NZ_LR890504:28234-28299 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References