Detailed information of TA system TA238836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4256893..4257566
• Replicon: chromosome
• Accession: NZ_CP093528
• Organism: Shinella zoogloeoides strain XJ20

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MOE34_RS21100
• Protein ID: WP_242219548.1
• Coordinates: 4257144..4257566 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0G3XGK1
• Locus tag: MOE34_RS21095
• Protein ID: WP_012110103.1
• Coordinates: 4256893..4257147 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOE34_RS21085	4254498..4255532	+	1035	WP_242219543.1	toprim domain-containing protein	-
MOE34_RS21090	4255880..4256806	+	927	WP_242219546.1	DUF2493 domain-containing protein	-
MOE34_RS21095	4256893..4257147	+	255	WP_012110103.1	plasmid stabilization protein	Antitoxin
MOE34_RS21100	4257144..4257566	+	423	WP_242219548.1	type II toxin-antitoxin system VapC family toxin	Toxin
MOE34_RS21105	4257848..4258015	+	168	WP_168168942.1	hypothetical protein	-
MOE34_RS21110	4258150..4258590	+	441	WP_061929712.1	hypothetical protein	-
MOE34_RS21115	4259163..4259489	+	327	WP_041535876.1	DUF736 domain-containing protein	-
MOE34_RS21120	4259795..4260061	+	267	WP_045811379.1	helix-turn-helix transcriptional regulator	-
MOE34_RS21125	4260158..4260418	+	261	WP_047167743.1	DUF2285 domain-containing protein	-
MOE34_RS21130	4260548..4260889	+	342	WP_242219549.1	DUF6499 domain-containing protein	-
MOE34_RS21135	4260780..4261310	+	531	WP_242219551.1	DUF2285 domain-containing protein	-
MOE34_RS21140	4261447..4261728	+	282	WP_242219553.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4203281..4310465	107184

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14985.14 Da
• Isoelectric Point: 4.5093

>T238836 WP_242219548.1 NZ_CP093528:4257144-4257566 [Shinella zoogloeoides]
MILLDTNVVSEAMKPAPDDAVRAWLDEQAAETLFLSSVTIAELMFGIGALPEGKRKERLTEALDGVMELFADRVLPFDVD
AARRYADLAVKARTAGKGFPTPDGYIAAIAAAKGFAVATRDNSAFEAANVTVIDPWKAGR

Nucleotide

• Length: 423 bp

>T238836 NZ_LR890500:c4951798-4951580 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9351.67 Da
• Isoelectric Point: 10.4317

>AT238836 WP_012110103.1 NZ_CP093528:4256893-4257147 [Shinella zoogloeoides]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDQARDKAPAKP
MSFE

Nucleotide

• Length: 255 bp

>AT238836 NZ_LR890500:c4952199-4951825 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0G3XGK1