Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2549942..2550533 Replicon chromosome
Accession NZ_CP093528
Organism Shinella zoogloeoides strain XJ20

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MOE34_RS12755 Protein ID WP_242217412.1
Coordinates 2549942..2550241 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MOE34_RS12760 Protein ID WP_242217414.1
Coordinates 2550243..2550533 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOE34_RS12740 2545828..2547096 - 1269 WP_242217404.1 cytochrome b N-terminal domain-containing protein -
MOE34_RS12745 2547111..2547689 - 579 WP_242217407.1 ubiquinol-cytochrome c reductase iron-sulfur subunit -
MOE34_RS12750 2547953..2549821 - 1869 WP_242217409.1 ABC transporter ATP-binding protein -
MOE34_RS12755 2549942..2550241 + 300 WP_242217412.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOE34_RS12760 2550243..2550533 + 291 WP_242217414.1 putative addiction module antidote protein Antitoxin
MOE34_RS12765 2550574..2552430 - 1857 WP_242217416.1 ABC transporter ATP-binding protein -
MOE34_RS12770 2552776..2553237 + 462 WP_242217418.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
MOE34_RS12775 2553241..2554521 - 1281 WP_242217420.1 hemolysin family protein -
MOE34_RS12780 2554645..2554902 - 258 WP_242217422.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(42-84)

Antitoxin

Uncharacterized protein HI1420

(8-92)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11071.77 Da        Isoelectric Point: 10.1820

>T238834 WP_242217412.1 NZ_CP093528:2549942-2550241 [Shinella zoogloeoides]
MAILIRQTDTFQKWERALNDPRARALIAARLNRVAYGLLGDVKSVGEGISEIRIHYGPGYRIYFTRRGNEIIVLLCGGDK
GTQKRDIVAARTLAAQLDD

Download         Length: 300 bp

>T238834 NZ_LR890500:4216184-4216468 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10098.57 Da        Isoelectric Point: 6.2163

>AT238834 WP_242217414.1 NZ_CP093528:2550243-2550533 [Shinella zoogloeoides]
MSKALHIYDPAEALTSDEAVDIFMKDAFESGDAGYIAHALGVVARAKGMSKVAGETGLAREALYRSLAADGNPTLKSMLT
IMHALGLELTSKRTGT

Download         Length: 291 bp

>AT238834 NZ_LR890500:4215952-4216194 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References