Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1222867..1223474 Replicon chromosome
Accession NZ_CP093528
Organism Shinella zoogloeoides strain XJ20

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MOE34_RS06275 Protein ID WP_242221980.1
Coordinates 1222867..1223163 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MOE34_RS06280 Protein ID WP_242221982.1
Coordinates 1223160..1223474 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOE34_RS06250 1218370..1218888 + 519 WP_242221967.1 hypothetical protein -
MOE34_RS06255 1218901..1219905 - 1005 WP_242221971.1 porphobilinogen synthase -
MOE34_RS06260 1220115..1220498 + 384 WP_242221973.1 DUF6163 family protein -
MOE34_RS06265 1220629..1221141 + 513 WP_242221975.1 MarR family winged helix-turn-helix transcriptional regulator -
MOE34_RS06270 1221424..1222746 + 1323 WP_242221978.1 L,D-transpeptidase family protein -
MOE34_RS06275 1222867..1223163 + 297 WP_242221980.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOE34_RS06280 1223160..1223474 + 315 WP_242221982.1 putative addiction module antidote protein Antitoxin
MOE34_RS06285 1223614..1224912 + 1299 WP_160784877.1 serine hydroxymethyltransferase -
MOE34_RS06290 1224980..1225459 + 480 WP_160784876.1 transcriptional regulator NrdR -
MOE34_RS06295 1225460..1226557 + 1098 WP_242221983.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
MOE34_RS06300 1226557..1227174 + 618 WP_242221985.1 riboflavin synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(6-102)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11139.70 Da        Isoelectric Point: 10.3618

>T238832 WP_242221980.1 NZ_CP093528:1222867-1223163 [Shinella zoogloeoides]
MFTLVASSKFEKWFGGLRDYRASARIRQRLARLEQGHFGDAKSVGEGVSELRVDYGPGYRVYFMRSGSVVVVLLCGGHKG
SQARDIEEARRIAREWKE

Download         Length: 297 bp

>T238832 NZ_LR890500:c3287852-3287484 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11367.14 Da        Isoelectric Point: 6.0741

>AT238832 WP_242221982.1 NZ_CP093528:1223160-1223474 [Shinella zoogloeoides]
MTMEEKITFRPFDLAHSLDSEEEIVEFLRVAFLQGDAAHIAHCLGIVARARNMAQLARDVGMSRPALYKALSGEGNPEFA
TVMKIMHALGIGLAPVSRKNDEAA

Download         Length: 315 bp

>AT238832 NZ_LR890500:c3288070-3287849 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References