Detailed information of TA system TA238830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 876515..877158
• Replicon: chromosome
• Accession: NZ_CP093528
• Organism: Shinella zoogloeoides strain XJ20

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MOE34_RS04405
• Protein ID: WP_242221378.1
• Coordinates: 876763..877158 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MOE34_RS04400
• Protein ID: WP_242221376.1
• Coordinates: 876515..876766 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOE34_RS04365	872172..872582	+	411	WP_242221364.1	DUF930 domain-containing protein	-
MOE34_RS04370	872618..873478	-	861	WP_242223750.1	VOC family protein	-
MOE34_RS04375	873780..874103	+	324	WP_242221366.1	TraR/DksA C4-type zinc finger protein	-
MOE34_RS04380	874209..874865	+	657	WP_242221368.1	hemolysin III family protein	-
MOE34_RS04385	874870..875370	-	501	WP_242221370.1	hypothetical protein	-
MOE34_RS04390	875486..875989	+	504	WP_242221372.1	GNAT family N-acetyltransferase	-
MOE34_RS04395	875990..876397	-	408	WP_242221374.1	peptide-methionine (R)-S-oxide reductase MsrB	-
MOE34_RS04400	876515..876766	+	252	WP_242221376.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MOE34_RS04405	876763..877158	+	396	WP_242221378.1	type II toxin-antitoxin system VapC family toxin	Toxin
MOE34_RS04410	877205..879541	+	2337	WP_242221380.1	putative monovalent cation/H+ antiporter subunit A	-
MOE34_RS04415	879538..879957	+	420	WP_242221382.1	Na(+)/H(+) antiporter subunit B	-
MOE34_RS04420	879957..880334	+	378	WP_242221384.1	Na+/H+ antiporter subunit C	-
MOE34_RS04425	880352..881893	+	1542	WP_242221386.1	Na+/H+ antiporter subunit D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	floR / sul1 / aadA2 / ere(A)	-	794913..1014253	219340

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14105.10 Da
• Isoelectric Point: 5.6383

>T238830 WP_242221378.1 NZ_CP093528:876763-877158 [Shinella zoogloeoides]
MIVLDTSALVAILTDEPERRVFNEAIARAAGRVMSAASLLETKMVLFARYGGSGVNALDAFLLRADIRIEPVTAAQAEIA
FDAFRHFGRGTGHAAHLNYGDCFSYALARENAAPLLFKGGDFARTDIETAL

Nucleotide

• Length: 396 bp

>T238830 NZ_LR890500:c1536690-1536588 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9264.55 Da
• Isoelectric Point: 5.1356

>AT238830 WP_242221376.1 NZ_CP093528:876515-876766 [Shinella zoogloeoides]
MPLNIKDEKAYALARELAETTGESLTRAVKISIEERLVRVRQAHVPRLADQLDRIALDCASLPVHDPRSADEILGYDESG
LPR

Nucleotide

• Length: 252 bp

>AT238830 NZ_LR890500:1536581-1536726 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT