Detailed information of TA system TA023883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1939142..1939664
• Replicon: chromosome
• Accession: NC_012779
• Organism: Edwardsiella ictaluri 93-146

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: NT01EI_RS08785
• Protein ID: WP_015871319.1
• Coordinates: 1939383..1939664 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: NT01EI_RS08780
• Protein ID: WP_015871318.1
• Coordinates: 1939142..1939393 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NT01EI_RS08750	1934298..1934960	-	663	WP_015871312.1	hypothetical protein	-
NT01EI_RS08755	1934960..1935541	-	582	WP_015871313.1	hypothetical protein	-
NT01EI_RS08760	1935541..1935984	-	444	WP_015871314.1	hypothetical protein	-
NT01EI_RS08765	1936026..1936421	-	396	WP_015871315.1	hypothetical protein	-
NT01EI_RS08770	1936579..1937835	-	1257	WP_015871316.1	N4-gp56 family major capsid protein	-
NT01EI_RS08775	1937853..1938854	-	1002	WP_015871317.1	hypothetical protein	-
NT01EI_RS08780	1939142..1939393	+	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
NT01EI_RS08785	1939383..1939664	+	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NT01EI_RS08790	1939736..1941850	-	2115	WP_015871320.1	hypothetical protein	-
NT01EI_RS08795	1941847..1943508	-	1662	WP_050977403.1	terminase	-
NT01EI_RS08800	1943501..1944277	-	777	WP_015871322.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1904680..1974943	70263

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T23883 WP_015871319.1 NC_012779:1939383-1939664 [Edwardsiella ictaluri 93-146]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T23883 NC_012779:1939383-1939664 [Edwardsiella ictaluri 93-146]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT23883 WP_015871318.1 NC_012779:1939142-1939393 [Edwardsiella ictaluri 93-146]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT23883 NC_012779:1939142-1939393 [Edwardsiella ictaluri 93-146]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3