Detailed information of TA system TA238824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1823621..1824098
• Replicon: chromosome
• Accession: NZ_CP093527
• Organism: Staphylococcus aureus strain 697R

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MPF55_RS08960
• Protein ID: WP_000052076.1
• Coordinates: 1823910..1824098 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MPF55_RS08955
• Protein ID: WP_001059690.1
• Coordinates: 1823621..1823881 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF55_RS08920 (1819013)	1819013..1819729	-	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-
MPF55_RS08925 (1819877)	1819877..1820299	+	423	WP_000974455.1	organic hydroperoxide resistance protein	-
MPF55_RS08930 (1820698)	1820698..1821192	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MPF55_RS08935 (1821348)	1821348..1821965	+	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
MPF55_RS08940 (1822038)	1822038..1822619	-	582	WP_001140697.1	histidine phosphatase family protein	-
MPF55_RS08945 (1822844)	1822844..1823080	+	237	WP_000368687.1	hypothetical protein	-
MPF55_RS08950 (1823077)	1823077..1823280	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MPF55_RS08955 (1823621)	1823621..1823881	+	261	WP_001059690.1	hypothetical protein	Antitoxin
MPF55_RS08960 (1823910)	1823910..1824098	+	189	WP_000052076.1	hypothetical protein	Toxin
MPF55_RS08965 (1824286)	1824286..1824549	+	264	Protein_1731	hypothetical protein	-
MPF55_RS08970 (1824609)	1824609..1825370	-	762	WP_001066124.1	IS21-like element helper ATPase IstB	-
MPF55_RS08975 (1825363)	1825363..1826655	-	1293	WP_000777467.1	IS21 family transposase	-
MPF55_RS08980 (1826748)	1826748..1827062	+	315	Protein_1734	hypothetical protein	-
MPF55_RS08985 (1827150)	1827150..1827434	+	285	WP_001004397.1	hypothetical protein	-
MPF55_RS08990 (1827496)	1827496..1827714	+	219	WP_000005888.1	hypothetical protein	-
MPF55_RS08995 (1828213)	1828213..1828413	-	201	WP_001059082.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1824609..1825373	764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T238824 WP_000052076.1 NZ_CP093527:1823910-1824098 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T238824 NZ_LR890493:3973281-3973499 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT238824 WP_001059690.1 NZ_CP093527:1823621-1823881 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT238824 NZ_LR890493:3972880-3973254 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56