Detailed information of TA system TA238823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1805869..1806401
• Replicon: chromosome
• Accession: NZ_CP093527
• Organism: Staphylococcus aureus strain 697R

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: MPF55_RS08815
• Protein ID: WP_001103942.1
• Coordinates: 1805869..1806189 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MPF55_RS08820
• Protein ID: WP_001058486.1
• Coordinates: 1806192..1806401 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF55_RS08785 (1801020)	1801020..1801361	-	342	WP_001190615.1	hypothetical protein	-
MPF55_RS08790 (1801878)	1801878..1802519	-	642	WP_001019764.1	hypothetical protein	-
MPF55_RS08795 (1802516)	1802516..1802800	-	285	WP_240696975.1	pathogenicity island protein	-
MPF55_RS08800 (1802802)	1802802..1803164	-	363	WP_001039168.1	hypothetical protein	-
MPF55_RS08805 (1803450)	1803450..1804919	-	1470	WP_000390454.1	virulence-associated E family protein	-
MPF55_RS08810 (1804936)	1804936..1805805	-	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
MPF55_RS08815 (1805869)	1805869..1806189	-	321	WP_001103942.1	DUF1474 family protein	Toxin
MPF55_RS08820 (1806192)	1806192..1806401	-	210	WP_001058486.1	hypothetical protein	Antitoxin
MPF55_RS08825 (1806394)	1806394..1806540	-	147	WP_000784875.1	hypothetical protein	-
MPF55_RS08830 (1806552)	1806552..1806824	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
MPF55_RS08835 (1806817)	1806817..1807080	-	264	WP_000243851.1	helix-turn-helix transcriptional regulator	-
MPF55_RS08840 (1807273)	1807273..1807605	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
MPF55_RS08845 (1807617)	1807617..1808075	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
MPF55_RS08850 (1808092)	1808092..1808523	+	432	WP_001228759.1	hypothetical protein	-
MPF55_RS08855 (1808594)	1808594..1809322	+	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
MPF55_RS08860 (1809346)	1809346..1810074	+	729	WP_000733774.1	staphylococcal enterotoxin type K	-
MPF55_RS08865 (1810163)	1810163..1811383	+	1221	WP_000266157.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk	1796069..1816819	20750

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T238823 WP_001103942.1 NZ_CP093527:c1806189-1805869 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T238823 NZ_LR890493:c2609547-2608225 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT238823 WP_001058486.1 NZ_CP093527:c1806401-1806192 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT238823 NZ_LR890493:c2609813-2609547 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: Q93CD4