Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1090499..1091091 Replicon chromosome
Accession NC_012779
Organism Edwardsiella ictaluri 93-146

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag NT01EI_RS04900 Protein ID WP_012847872.1
Coordinates 1090499..1090702 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag NT01EI_RS04905 Protein ID WP_015870487.1
Coordinates 1090723..1091091 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT01EI_RS04870 1085719..1086180 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
NT01EI_RS19935 1086209..1086376 - 168 WP_015870481.1 hypothetical protein -
NT01EI_RS04875 1086479..1086817 + 339 WP_015870482.1 P-II family nitrogen regulator -
NT01EI_RS04880 1086839..1088119 + 1281 WP_035610376.1 ammonium transporter AmtB -
NT01EI_RS04885 1088153..1089019 - 867 WP_015870484.1 acyl-CoA thioesterase II -
NT01EI_RS04890 1089065..1089394 - 330 WP_015870485.1 MGMT family protein -
NT01EI_RS19460 1090372..1090479 + 108 Protein_961 IS5/IS1182 family transposase -
NT01EI_RS04900 1090499..1090702 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
NT01EI_RS04905 1090723..1091091 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
NT01EI_RS04910 1091451..1094603 - 3153 WP_015870488.1 multidrug efflux RND transporter permease subunit -
NT01EI_RS04915 1094647..1095831 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T23882 WP_012847872.1 NC_012779:c1090702-1090499 [Edwardsiella ictaluri 93-146]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T23882 NC_012779:c1090702-1090499 [Edwardsiella ictaluri 93-146]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT23882 WP_015870487.1 NC_012779:c1091091-1090723 [Edwardsiella ictaluri 93-146]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT23882 NC_012779:c1091091-1090723 [Edwardsiella ictaluri 93-146]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References