Detailed information of TA system TA023881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 871568..872231
• Replicon: chromosome
• Accession: NC_012779
• Organism: Edwardsiella ictaluri 93-146

Toxin (Protein)

• Gene name: tad
• Uniprot ID: C5B7U4
• Locus tag: NT01EI_RS03910
• Protein ID: WP_015870280.1
• Coordinates: 871887..872231 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: NT01EI_RS03905
• Protein ID: WP_015870279.1
• Coordinates: 871568..871885 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NT01EI_RS03870	866899..867447	+	549	WP_015870271.1	YaeQ family protein	-
NT01EI_RS03875	867449..867865	+	417	WP_015870272.1	aminoacyl-tRNA hydrolase	-
NT01EI_RS03880	867962..868639	+	678	WP_015870273.1	envelope stress response activation lipoprotein NlpE	-
NT01EI_RS03885	868661..868921	-	261	WP_015870274.1	YfhL family 4Fe-4S dicluster ferredoxin	-
NT01EI_RS19430	869526..869804	+	279	WP_133175613.1	hypothetical protein	-
NT01EI_RS17650	870749..870928	+	180	WP_071525714.1	hypothetical protein	-
NT01EI_RS03900	871158..871535	+	378	WP_015870278.1	type II toxin-antitoxin system death-on-curing family toxin	-
NT01EI_RS03905	871568..871885	-	318	WP_015870279.1	helix-turn-helix domain-containing protein	Antitoxin
NT01EI_RS03910	871887..872231	-	345	WP_015870280.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NT01EI_RS17655	872403..872672	-	270	Protein_765	head completion/stabilization protein	-
NT01EI_RS19435	872704..873443	+	740	Protein_766	phage portal protein	-
NT01EI_RS03920	874467..875314	-	848	Protein_767	MurR/RpiR family transcriptional regulator	-
NT01EI_RS03925	875491..876114	+	624	WP_015870285.1	phosphatidylglycerophosphatase C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12544.34 Da
• Isoelectric Point: 9.8474

>T23881 WP_015870280.1 NC_012779:c872231-871887 [Edwardsiella ictaluri 93-146]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Nucleotide

• Length: 345 bp

>T23881 NC_012779:c872231-871887 [Edwardsiella ictaluri 93-146]
ATGAAGTCACTATATTGGGTTGGTAGTACAAAAAAAGACCTCCAGTCATTGCCTGAAGAAGTACAGGATATTTTCGGCTA
TGCCCTGCATCTGGCACAGGTAGGAGGTAAACACTCACAGACCAAGCCACTGAAGGGGTTTAGTGGAGCTGGCGTACTTG
AGGTAGTAGAAGACTTTCTCGGTGATACTTATCGTGCAGTGTATACCGTTAAGTTCGGTGATGCCGTCTACGTTTCGCAC
GTATTCCAGAAAAAGTCTTCATCGGGAATCGCCACGCCAAAGCTCAATATGGACAAGATCCGCGAACGGCTAAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11480.41 Da
• Isoelectric Point: 10.2058

>AT23881 WP_015870279.1 NC_012779:c871885-871568 [Edwardsiella ictaluri 93-146]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Nucleotide

• Length: 318 bp

>AT23881 NC_012779:c871885-871568 [Edwardsiella ictaluri 93-146]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGTCGATATTGGCAGAGATGATGCCGAGGAAATGCTGTTAAA
AGCTCAGCTTGCCACCACTATTGGAAACATCATTAAAAGCCGTAGCCTGACGCAAGAACAAGCAGCAAAACTGCTGGGGA
TGACGCAGCCCAAACTGTCCAATATGCTGCGTGGGCAGTTCCGGGGCATCAGTGAAGCCAAAATGCTGGAATGTCTGACC
CGCTTAGGGCGCGACGTGCAAATCGTGGTTGGAAAGCCGCGCCGGACGCCGGGTAGCGTGAAAGTAGTGTTAGCCTGA

Structures

Toxin

• AlphaFold DB: C5B7U4