Detailed information of TA system TA238809

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5015279..5016080
• Replicon: chromosome
• Accession: NZ_CP093501
• Organism: Klebsiella pneumoniae strain VA04

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MO409_RS24690
• Protein ID: WP_064143481.1
• Coordinates: 5015703..5016080 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: MO409_RS24685
• Protein ID: WP_064143482.1
• Coordinates: 5015279..5015656 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO409_RS24660 (5012704)	5012704..5012937	+	234	WP_001117568.1	DUF905 family protein	-
MO409_RS24665 (5013028)	5013028..5013846	+	819	WP_001610805.1	DUF932 domain-containing protein	-
MO409_RS24670 (5013938)	5013938..5014423	+	486	WP_000214414.1	antirestriction protein	-
MO409_RS24675 (5014439)	5014439..5014915	+	477	WP_110225547.1	RadC family protein	-
MO409_RS24680 (5014978)	5014978..5015199	+	222	WP_110225546.1	DUF987 domain-containing protein	-
MO409_RS24685 (5015279)	5015279..5015656	+	378	WP_064143482.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MO409_RS24690 (5015703)	5015703..5016080	+	378	WP_064143481.1	TA system toxin CbtA family protein	Toxin
MO409_RS24695 (5016077)	5016077..5016274	+	198	Protein_4844	DUF5983 family protein	-
MO409_RS24700 (5016302)	5016302..5016499	+	198	WP_023563519.1	DUF957 domain-containing protein	-
MO409_RS24705 (5016584)	5016584..5017426	+	843	WP_064143480.1	DUF4942 domain-containing protein	-
MO409_RS24710 (5017492)	5017492..5017686	-	195	WP_283485661.1	hypothetical protein	-
MO409_RS24720 (5019193)	5019193..5019483	-	291	WP_004153693.1	PerC family transcriptional regulator	-
MO409_RS24725 (5019678)	5019678..5019800	+	123	WP_004146686.1	hypothetical protein	-
MO409_RS24730 (5019795)	5019795..5020361	-	567	WP_002885396.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5000293..5020373	20080

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14037.93 Da
• Isoelectric Point: 7.2922

>T238809 WP_064143481.1 NZ_CP093501:5015703-5016080 [Klebsiella pneumoniae]
MKTLPDTHEREASRCSSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCAHSQLINSIDILRARRATGLLTRSNYRTVNDIIRGKDAEAKQ

Nucleotide

• Length: 378 bp

>T238809 NZ_LR890490:796005-796415 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGGTCTGGTTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13751.48 Da
• Isoelectric Point: 5.4906

>AT238809 WP_064143482.1 NZ_CP093501:5015279-5015656 [Klebsiella pneumoniae]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Nucleotide

• Length: 378 bp

>AT238809 NZ_LR890490:795758-796024 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA