Detailed information of TA system TA238808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4857892..4858408
• Replicon: chromosome
• Accession: NZ_CP093501
• Organism: Klebsiella pneumoniae strain VA04

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MO409_RS23925
• Protein ID: WP_023317444.1
• Coordinates: 4857892..4858176 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MO409_RS23930
• Protein ID: WP_002886901.1
• Coordinates: 4858166..4858408 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO409_RS23900 (4853287)	4853287..4853550	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
MO409_RS23905 (4853680)	4853680..4853853	+	174	WP_032408826.1	hypothetical protein	-
MO409_RS23910 (4853856)	4853856..4854599	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
MO409_RS23915 (4854956)	4854956..4857094	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
MO409_RS23920 (4857424)	4857424..4857888	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MO409_RS23925 (4857892)	4857892..4858176	-	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MO409_RS23930 (4858166)	4858166..4858408	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MO409_RS23935 (4858486)	4858486..4860396	-	1911	WP_004152270.1	PRD domain-containing protein	-
MO409_RS23940 (4860419)	4860419..4861573	-	1155	WP_002886900.1	lactonase family protein	-
MO409_RS23945 (4861640)	4861640..4862380	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T238808 WP_023317444.1 NZ_CP093501:c4858176-4857892 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T238808 NZ_LR890490:717898-718383 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCAATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT238808 WP_002886901.1 NZ_CP093501:c4858408-4858166 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT238808 NZ_LR890490:717608-717901 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0