Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 814487..815144 Replicon chromosome
Accession NZ_CP093501
Organism Klebsiella pneumoniae strain VA04

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MO409_RS04030 Protein ID WP_002916310.1
Coordinates 814734..815144 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MO409_RS04025 Protein ID WP_002916312.1
Coordinates 814487..814753 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO409_RS04000 (809695) 809695..811128 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MO409_RS04005 (811247) 811247..811975 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MO409_RS04010 (812025) 812025..812336 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MO409_RS04015 (812500) 812500..813159 + 660 WP_002916317.1 hemolysin III family protein -
MO409_RS04020 (813258) 813258..814241 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
MO409_RS04025 (814487) 814487..814753 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MO409_RS04030 (814734) 814734..815144 + 411 WP_002916310.1 protein YgfX Toxin
MO409_RS04035 (815151) 815151..815672 - 522 WP_004144730.1 flavodoxin FldB -
MO409_RS04040 (815773) 815773..816669 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MO409_RS04045 (816692) 816692..817405 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MO409_RS04050 (817411) 817411..819144 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T238796 WP_002916310.1 NZ_CP093501:814734-815144 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T238796 NZ_LR890484:349018-349365 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT238796 WP_002916312.1 NZ_CP093501:814487-814753 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238796 NZ_LR890484:349365-349664 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References