Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4680411..4681212 Replicon chromosome
Accession NZ_CP093489
Organism Klebsiella pneumoniae strain VA126

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MO410_RS22865 Protein ID WP_064143481.1
Coordinates 4680835..4681212 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MO410_RS22860 Protein ID WP_064143482.1
Coordinates 4680411..4680788 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO410_RS22835 (4677836) 4677836..4678069 + 234 WP_001117568.1 DUF905 family protein -
MO410_RS22840 (4678160) 4678160..4678978 + 819 WP_001610805.1 DUF932 domain-containing protein -
MO410_RS22845 (4679070) 4679070..4679555 + 486 WP_000214414.1 antirestriction protein -
MO410_RS22850 (4679571) 4679571..4680047 + 477 WP_110225547.1 RadC family protein -
MO410_RS22855 (4680110) 4680110..4680331 + 222 WP_110225546.1 DUF987 domain-containing protein -
MO410_RS22860 (4680411) 4680411..4680788 + 378 WP_064143482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MO410_RS22865 (4680835) 4680835..4681212 + 378 WP_064143481.1 TA system toxin CbtA family protein Toxin
MO410_RS22870 (4681209) 4681209..4681406 + 198 Protein_4489 DUF5983 family protein -
MO410_RS22875 (4681434) 4681434..4681631 + 198 WP_023563519.1 DUF957 domain-containing protein -
MO410_RS22880 (4681716) 4681716..4682558 + 843 WP_064143480.1 DUF4942 domain-containing protein -
MO410_RS22885 (4682624) 4682624..4682818 - 195 WP_283485661.1 hypothetical protein -
MO410_RS22895 (4684325) 4684325..4684615 - 291 WP_004153693.1 PerC family transcriptional regulator -
MO410_RS22900 (4684810) 4684810..4684932 + 123 WP_004146686.1 hypothetical protein -
MO410_RS22905 (4684927) 4684927..4685493 - 567 WP_002885396.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4665425..4685505 20080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.93 Da        Isoelectric Point: 7.2922

>T238770 WP_064143481.1 NZ_CP093489:4680835-4681212 [Klebsiella pneumoniae]
MKTLPDTHEREASRCSSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCAHSQLINSIDILRARRATGLLTRSNYRTVNDIIRGKDAEAKQ

Download         Length: 378 bp

>T238770 NZ_LR890471:2855973-2857295 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGAGAGCAGATGTTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13751.48 Da        Isoelectric Point: 5.4906

>AT238770 WP_064143482.1 NZ_CP093489:4680411-4680788 [Klebsiella pneumoniae]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Download         Length: 378 bp

>AT238770 NZ_LR890471:2855707-2855973 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References