Detailed information of TA system TA238769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4521114..4521630
• Replicon: chromosome
• Accession: NZ_CP093489
• Organism: Klebsiella pneumoniae strain VA126

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MO410_RS22095
• Protein ID: WP_023317444.1
• Coordinates: 4521114..4521398 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MO410_RS22100
• Protein ID: WP_002886901.1
• Coordinates: 4521388..4521630 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO410_RS22070 (4516509)	4516509..4516772	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
MO410_RS22075 (4516902)	4516902..4517075	+	174	WP_032408826.1	hypothetical protein	-
MO410_RS22080 (4517078)	4517078..4517821	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
MO410_RS22085 (4518178)	4518178..4520316	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
MO410_RS22090 (4520646)	4520646..4521110	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MO410_RS22095 (4521114)	4521114..4521398	-	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MO410_RS22100 (4521388)	4521388..4521630	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MO410_RS22105 (4521708)	4521708..4523618	-	1911	WP_004152270.1	PRD domain-containing protein	-
MO410_RS22110 (4523641)	4523641..4524795	-	1155	WP_002886900.1	lactonase family protein	-
MO410_RS22115 (4524862)	4524862..4525602	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T238769 WP_023317444.1 NZ_CP093489:c4521398-4521114 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T238769 NZ_LR890471:826812-827222 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT238769 WP_002886901.1 NZ_CP093489:c4521630-4521388 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT238769 NZ_LR890471:826565-826831 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0