Detailed information of TA system TA238766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2499151..2500739
• Replicon: chromosome
• Accession: NZ_CP093489
• Organism: Klebsiella pneumoniae strain VA126

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MO410_RS12260
• Protein ID: WP_032436337.1
• Coordinates: 2499151..2500473 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: MO410_RS12265
• Protein ID: WP_002904790.1
• Coordinates: 2500473..2500739 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO410_RS12245 (2494208)	2494208..2496709	+	2502	WP_087836359.1	fimbria/pilus outer membrane usher protein	-
MO410_RS12250 (2496697)	2496697..2497701	+	1005	WP_032436338.1	fimbrial protein	-
MO410_RS12255 (2497842)	2497842..2499134	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MO410_RS12260 (2499151)	2499151..2500473	-	1323	WP_032436337.1	type II toxin-antitoxin system HipA family toxin	Toxin
MO410_RS12265 (2500473)	2500473..2500739	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MO410_RS12270 (2501126)	2501126..2501452	-	327	WP_032436336.1	hydroxyisourate hydrolase	-
MO410_RS12275 (2501449)	2501449..2501949	-	501	WP_032436335.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MO410_RS12280 (2501927)	2501927..2503306	-	1380	Protein_2413	nucleobase:cation symporter-2 family protein	-
MO410_RS12285 (2503652)	2503652..2504806	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MO410_RS12290 (2504787)	2504787..2505710	-	924	WP_032436334.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49106.39 Da
• Isoelectric Point: 7.5617

>T238766 WP_032436337.1 NZ_CP093489:c2500473-2499151 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T238766 NZ_LR890471:331979-332347 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT238766 WP_002904790.1 NZ_CP093489:c2500739-2500473 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT238766 NZ_LR890471:331761-331982 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8