Detailed information of TA system TA238751

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4806409..4807210
• Replicon: chromosome
• Accession: NZ_CP093486
• Organism: Klebsiella pneumoniae strain VA172

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MO413_RS23550
• Protein ID: WP_064143481.1
• Coordinates: 4806833..4807210 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: MO413_RS23545
• Protein ID: WP_064143482.1
• Coordinates: 4806409..4806786 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO413_RS23520 (4803834)	4803834..4804067	+	234	WP_001117568.1	DUF905 family protein	-
MO413_RS23525 (4804158)	4804158..4804976	+	819	WP_001610805.1	DUF932 domain-containing protein	-
MO413_RS23530 (4805068)	4805068..4805553	+	486	WP_000214414.1	antirestriction protein	-
MO413_RS23535 (4805569)	4805569..4806045	+	477	WP_110225547.1	RadC family protein	-
MO413_RS23540 (4806108)	4806108..4806329	+	222	WP_110225546.1	DUF987 domain-containing protein	-
MO413_RS23545 (4806409)	4806409..4806786	+	378	WP_064143482.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MO413_RS23550 (4806833)	4806833..4807210	+	378	WP_064143481.1	TA system toxin CbtA family protein	Toxin
MO413_RS23555 (4807207)	4807207..4807404	+	198	Protein_4614	DUF5983 family protein	-
MO413_RS23560 (4807432)	4807432..4807629	+	198	WP_023563519.1	DUF957 domain-containing protein	-
MO413_RS23565 (4807714)	4807714..4808556	+	843	WP_064143480.1	DUF4942 domain-containing protein	-
MO413_RS23575 (4810649)	4810649..4810939	-	291	WP_004153693.1	PerC family transcriptional regulator	-
MO413_RS23580 (4811134)	4811134..4811256	+	123	WP_004146686.1	hypothetical protein	-
MO413_RS23585 (4811251)	4811251..4811817	-	567	WP_002885396.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4791423..4811829	20406

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14037.93 Da
• Isoelectric Point: 7.2922

>T238751 WP_064143481.1 NZ_CP093486:4806833-4807210 [Klebsiella pneumoniae]
MKTLPDTHEREASRCSSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCAHSQLINSIDILRARRATGLLTRSNYRTVNDIIRGKDAEAKQ

Nucleotide

• Length: 378 bp

>T238751 NZ_LR890466:c3350362-3349985 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13751.48 Da
• Isoelectric Point: 5.4906

>AT238751 WP_064143482.1 NZ_CP093486:4806409-4806786 [Klebsiella pneumoniae]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Nucleotide

• Length: 378 bp

>AT238751 NZ_LR890466:c3350819-3350451 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA