Detailed information of TA system TA238750

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4649799..4650315
• Replicon: chromosome
• Accession: NZ_CP093486
• Organism: Klebsiella pneumoniae strain VA172

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MO413_RS22795
• Protein ID: WP_023317444.1
• Coordinates: 4649799..4650083 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MO413_RS22800
• Protein ID: WP_002886901.1
• Coordinates: 4650073..4650315 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO413_RS22770 (4645194)	4645194..4645457	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
MO413_RS22775 (4645587)	4645587..4645760	+	174	WP_032408826.1	hypothetical protein	-
MO413_RS22780 (4645763)	4645763..4646506	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
MO413_RS22785 (4646863)	4646863..4649001	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
MO413_RS22790 (4649331)	4649331..4649795	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MO413_RS22795 (4649799)	4649799..4650083	-	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MO413_RS22800 (4650073)	4650073..4650315	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MO413_RS22805 (4650393)	4650393..4652303	-	1911	WP_004152270.1	PRD domain-containing protein	-
MO413_RS22810 (4652326)	4652326..4653480	-	1155	WP_002886900.1	lactonase family protein	-
MO413_RS22815 (4653547)	4653547..4654287	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T238750 WP_023317444.1 NZ_CP093486:c4650083-4649799 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T238750 NZ_LR890466:c3074124-3073813 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT238750 WP_002886901.1 NZ_CP093486:c4650315-4650073 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT238750 NZ_LR890466:c3073812-3073522 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0