Detailed information of TA system TA238747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2621939..2623527
• Replicon: chromosome
• Accession: NZ_CP093486
• Organism: Klebsiella pneumoniae strain VA172

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MO413_RS12930
• Protein ID: WP_032436337.1
• Coordinates: 2621939..2623261 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: MO413_RS12935
• Protein ID: WP_002904790.1
• Coordinates: 2623261..2623527 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO413_RS12915 (2616996)	2616996..2619497	+	2502	WP_087836359.1	fimbria/pilus outer membrane usher protein	-
MO413_RS12920 (2619485)	2619485..2620489	+	1005	WP_032436338.1	fimbrial protein	-
MO413_RS12925 (2620630)	2620630..2621922	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MO413_RS12930 (2621939)	2621939..2623261	-	1323	WP_032436337.1	type II toxin-antitoxin system HipA family toxin	Toxin
MO413_RS12935 (2623261)	2623261..2623527	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MO413_RS12940 (2623914)	2623914..2624240	-	327	WP_032436336.1	hydroxyisourate hydrolase	-
MO413_RS12945 (2624237)	2624237..2624737	-	501	WP_032436335.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MO413_RS12950 (2624715)	2624715..2626094	-	1380	Protein_2535	nucleobase:cation symporter-2 family protein	-
MO413_RS12955 (2626440)	2626440..2627594	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MO413_RS12960 (2627575)	2627575..2628498	-	924	WP_032436334.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49106.39 Da
• Isoelectric Point: 7.5617

>T238747 WP_032436337.1 NZ_CP093486:c2623261-2621939 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T238747 NZ_LR890466:c2615504-2615154 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT238747 WP_002904790.1 NZ_CP093486:c2623527-2623261 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT238747 NZ_LR890466:c2615749-2615498 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8