Detailed information of TA system TA238731

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4965539..4966340
• Replicon: chromosome
• Accession: NZ_CP093481
• Organism: Klebsiella pneumoniae strain VA564

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MO411_RS24365
• Protein ID: WP_064143481.1
• Coordinates: 4965963..4966340 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: MO411_RS24360
• Protein ID: WP_064143482.1
• Coordinates: 4965539..4965916 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO411_RS24335 (4962964)	4962964..4963197	+	234	WP_001117568.1	DUF905 family protein	-
MO411_RS24340 (4963288)	4963288..4964106	+	819	WP_001610805.1	DUF932 domain-containing protein	-
MO411_RS24345 (4964198)	4964198..4964683	+	486	WP_000214414.1	antirestriction protein	-
MO411_RS24350 (4964699)	4964699..4965175	+	477	WP_110225547.1	RadC family protein	-
MO411_RS24355 (4965238)	4965238..4965459	+	222	WP_110225546.1	DUF987 domain-containing protein	-
MO411_RS24360 (4965539)	4965539..4965916	+	378	WP_064143482.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MO411_RS24365 (4965963)	4965963..4966340	+	378	WP_064143481.1	TA system toxin CbtA family protein	Toxin
MO411_RS24370 (4966337)	4966337..4966534	+	198	Protein_4777	DUF5983 family protein	-
MO411_RS24375 (4966562)	4966562..4966759	+	198	WP_023563519.1	DUF957 domain-containing protein	-
MO411_RS24380 (4966844)	4966844..4967686	+	843	WP_064143480.1	DUF4942 domain-containing protein	-
MO411_RS24390 (4969779)	4969779..4970069	-	291	WP_004153693.1	PerC family transcriptional regulator	-
MO411_RS24395 (4970264)	4970264..4970386	+	123	WP_004146686.1	hypothetical protein	-
MO411_RS24400 (4970381)	4970381..4970947	-	567	WP_002885396.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4950553..4970959	20406

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14037.93 Da
• Isoelectric Point: 7.2922

>T238731 WP_064143481.1 NZ_CP093481:4965963-4966340 [Klebsiella pneumoniae]
MKTLPDTHEREASRCSSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCAHSQLINSIDILRARRATGLLTRSNYRTVNDIIRGKDAEAKQ

Nucleotide

• Length: 378 bp

>T238731 NZ_LR890464:c4859730-4859446 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13751.48 Da
• Isoelectric Point: 5.4906

>AT238731 WP_064143482.1 NZ_CP093481:4965539-4965916 [Klebsiella pneumoniae]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Nucleotide

• Length: 378 bp

>AT238731 NZ_LR890464:c4859962-4859720 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA