Detailed information of TA system TA238730

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4808929..4809445
• Replicon: chromosome
• Accession: NZ_CP093481
• Organism: Klebsiella pneumoniae strain VA564

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MO411_RS23610
• Protein ID: WP_023317444.1
• Coordinates: 4808929..4809213 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MO411_RS23615
• Protein ID: WP_002886901.1
• Coordinates: 4809203..4809445 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO411_RS23585 (4804324)	4804324..4804587	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
MO411_RS23590 (4804717)	4804717..4804890	+	174	WP_032408826.1	hypothetical protein	-
MO411_RS23595 (4804893)	4804893..4805636	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
MO411_RS23600 (4805993)	4805993..4808131	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
MO411_RS23605 (4808461)	4808461..4808925	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MO411_RS23610 (4808929)	4808929..4809213	-	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MO411_RS23615 (4809203)	4809203..4809445	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MO411_RS23620 (4809523)	4809523..4811433	-	1911	WP_004152270.1	PRD domain-containing protein	-
MO411_RS23625 (4811456)	4811456..4812610	-	1155	WP_002886900.1	lactonase family protein	-
MO411_RS23630 (4812677)	4812677..4813417	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T238730 WP_023317444.1 NZ_CP093481:c4809213-4808929 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T238730 NZ_LR890464:c4694066-4693533 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT238730 WP_002886901.1 NZ_CP093481:c4809445-4809203 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT238730 NZ_LR890464:c4694343-4694077 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0