Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4987287..4987803 Replicon chromosome
Accession NZ_CP093476
Organism Klebsiella pneumoniae strain VA569

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MO417_RS24835 Protein ID WP_002886902.1
Coordinates 4987287..4987571 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MO417_RS24840 Protein ID WP_002886901.1
Coordinates 4987561..4987803 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO417_RS24810 (MO417_24785) 4982771..4983034 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MO417_RS24815 (MO417_24790) 4983164..4983337 + 174 WP_002886906.1 hypothetical protein -
MO417_RS24820 (MO417_24795) 4983340..4984083 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MO417_RS24825 (MO417_24800) 4984440..4986578 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MO417_RS24830 (MO417_24805) 4986819..4987283 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MO417_RS24835 (MO417_24810) 4987287..4987571 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MO417_RS24840 (MO417_24815) 4987561..4987803 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MO417_RS24845 (MO417_24820) 4987881..4989791 - 1911 WP_004152270.1 PRD domain-containing protein -
MO417_RS24850 (MO417_24825) 4989814..4990968 - 1155 WP_002886900.1 lactonase family protein -
MO417_RS24855 (MO417_24830) 4991034..4991774 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T238705 WP_002886902.1 NZ_CP093476:c4987571-4987287 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T238705 NZ_LR890456:c5033998-5033615 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT238705 WP_002886901.1 NZ_CP093476:c4987803-4987561 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT238705 NZ_LR890456:c5034240-5033998 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCACGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References