Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4234512..4235131 Replicon chromosome
Accession NZ_CP093476
Organism Klebsiella pneumoniae strain VA569

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MO417_RS21150 Protein ID WP_002892050.1
Coordinates 4234913..4235131 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MO417_RS21145 Protein ID WP_002892066.1
Coordinates 4234512..4234886 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO417_RS21135 (MO417_21115) 4229664..4230857 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MO417_RS21140 (MO417_21120) 4230880..4234026 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MO417_RS21145 (MO417_21125) 4234512..4234886 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MO417_RS21150 (MO417_21130) 4234913..4235131 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MO417_RS21155 (MO417_21135) 4235290..4235856 + 567 WP_002892030.1 maltose O-acetyltransferase -
MO417_RS21160 (MO417_21140) 4235828..4235968 - 141 WP_004147370.1 hypothetical protein -
MO417_RS21165 (MO417_21145) 4235989..4236459 + 471 WP_002892026.1 YlaC family protein -
MO417_RS21170 (MO417_21150) 4236434..4237885 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MO417_RS21175 (MO417_21155) 4237986..4238684 + 699 WP_002892021.1 GNAT family protein -
MO417_RS21180 (MO417_21160) 4238681..4238821 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MO417_RS21185 (MO417_21165) 4238821..4239084 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T238703 WP_002892050.1 NZ_CP093476:4234913-4235131 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T238703 NZ_LR890456:c4544962-4544678 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGATGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT238703 WP_002892066.1 NZ_CP093476:4234512-4234886 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT238703 NZ_LR890456:c4545194-4544952 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References