Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4874755..4875271 Replicon chromosome
Accession NZ_CP093471
Organism Klebsiella pneumoniae strain VA591

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag MO415_RS23625 Protein ID WP_009309309.1
Coordinates 4874755..4875039 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MO415_RS23630 Protein ID WP_101972099.1
Coordinates 4875029..4875271 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO415_RS23600 (4870150) 4870150..4870413 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
MO415_RS23605 (4870543) 4870543..4870716 + 174 WP_032414379.1 hypothetical protein -
MO415_RS23610 (4870719) 4870719..4871462 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MO415_RS23615 (4871819) 4871819..4873957 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MO415_RS23620 (4874287) 4874287..4874751 + 465 WP_101972100.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MO415_RS23625 (4874755) 4874755..4875039 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MO415_RS23630 (4875029) 4875029..4875271 - 243 WP_101972099.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MO415_RS23635 (4875349) 4875349..4877259 - 1911 WP_101972098.1 PRD domain-containing protein -
MO415_RS23640 (4877282) 4877282..4878436 - 1155 WP_023159544.1 lactonase family protein -
MO415_RS23645 (4878503) 4878503..4879243 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T238686 WP_009309309.1 NZ_CP093471:c4875039-4874755 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T238686 NZ_LR890446:1984733-1984835 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9061.61 Da        Isoelectric Point: 6.3116

>AT238686 WP_101972099.1 NZ_CP093471:c4875271-4875029 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVCLDDL

Download         Length: 243 bp

>AT238686 NZ_LR890446:c1984842-1984697 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure

References