Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4075858..4076477 Replicon chromosome
Accession NZ_CP093471
Organism Klebsiella pneumoniae strain VA591

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MO415_RS19840 Protein ID WP_002892050.1
Coordinates 4076259..4076477 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MO415_RS19835 Protein ID WP_002892066.1
Coordinates 4075858..4076232 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO415_RS19825 (4071010) 4071010..4072203 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MO415_RS19830 (4072226) 4072226..4075372 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MO415_RS19835 (4075858) 4075858..4076232 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MO415_RS19840 (4076259) 4076259..4076477 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MO415_RS19845 (4076636) 4076636..4077202 + 567 WP_002892030.1 maltose O-acetyltransferase -
MO415_RS19850 (4077174) 4077174..4077314 - 141 WP_004147370.1 hypothetical protein -
MO415_RS19855 (4077335) 4077335..4077805 + 471 WP_002892026.1 YlaC family protein -
MO415_RS19860 (4077780) 4077780..4079230 - 1451 Protein_3899 PLP-dependent aminotransferase family protein -
MO415_RS19865 (4079331) 4079331..4080029 + 699 WP_002892021.1 GNAT family protein -
MO415_RS19870 (4080026) 4080026..4080166 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MO415_RS19875 (4080166) 4080166..4080429 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T238684 WP_002892050.1 NZ_CP093471:4076259-4076477 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T238684 NZ_LR890446:773498-773983 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT238684 WP_002892066.1 NZ_CP093471:4075858-4076232 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT238684 NZ_LR890446:773208-773501 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References