Detailed information of TA system TA238682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2679794..2681382
• Replicon: chromosome
• Accession: NZ_CP093471
• Organism: Klebsiella pneumoniae strain VA591

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486MZ73
• Locus tag: MO415_RS13100
• Protein ID: WP_009485244.1
• Coordinates: 2679794..2681116 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: MO415_RS13105
• Protein ID: WP_002904790.1
• Coordinates: 2681116..2681382 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO415_RS13085 (2674850)	2674850..2677351	+	2502	WP_009485242.1	fimbria/pilus outer membrane usher protein	-
MO415_RS13090 (2677339)	2677339..2678343	+	1005	WP_009485243.1	fimbrial protein	-
MO415_RS13095 (2678485)	2678485..2679777	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MO415_RS13100 (2679794)	2679794..2681116	-	1323	WP_009485244.1	type II toxin-antitoxin system HipA family toxin	Toxin
MO415_RS13105 (2681116)	2681116..2681382	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MO415_RS13110 (2681648)	2681648..2681974	-	327	WP_009485245.1	hydroxyisourate hydrolase	-
MO415_RS13115 (2681971)	2681971..2682471	-	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MO415_RS13120 (2682449)	2682449..2683828	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
MO415_RS13125 (2684174)	2684174..2685328	+	1155	WP_009485247.1	FAD-dependent urate hydroxylase HpxO	-
MO415_RS13130 (2685309)	2685309..2686232	-	924	WP_283459982.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49157.50 Da
• Isoelectric Point: 7.5062

>T238682 WP_009485244.1 NZ_CP093471:c2681116-2679794 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T238682 NZ_LR890446:339280-339648 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGATGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT238682 WP_002904790.1 NZ_CP093471:c2681382-2681116 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT238682 NZ_LR890446:339062-339283 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A486MZ73

Antitoxin

• AlphaFold DB: A0A0H3GXD8