Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4282865..4283522 Replicon chromosome
Accession NZ_CP093465
Organism Klebsiella pneumoniae strain VA681

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MO412_RS20930 Protein ID WP_002916310.1
Coordinates 4282865..4283275 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MO412_RS20935 Protein ID WP_002916312.1
Coordinates 4283256..4283522 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO412_RS20910 (MO412_20890) 4278865..4280598 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
MO412_RS20915 (MO412_20895) 4280604..4281317 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MO412_RS20920 (MO412_20900) 4281340..4282236 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MO412_RS20925 (MO412_20905) 4282337..4282858 + 522 WP_002916308.1 flavodoxin FldB -
MO412_RS20930 (MO412_20910) 4282865..4283275 - 411 WP_002916310.1 protein YgfX Toxin
MO412_RS20935 (MO412_20915) 4283256..4283522 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MO412_RS20940 (MO412_20920) 4283768..4284751 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MO412_RS20945 (MO412_20925) 4284902..4285561 - 660 WP_002916317.1 hemolysin III family protein -
MO412_RS20950 (MO412_20930) 4285725..4286036 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MO412_RS20955 (MO412_20935) 4286086..4286814 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MO412_RS20960 (MO412_20940) 4286933..4288366 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T238667 WP_002916310.1 NZ_CP093465:c4283275-4282865 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T238667 NZ_LR890430:28345-28503 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT238667 WP_002916312.1 NZ_CP093465:c4283522-4283256 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238667 NZ_LR890430:28234-28299 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References