23866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2660949..2661616 Replicon chromosome
Accession NC_012759
Organism Escherichia coli BW2952

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag BWG_RS13230 Protein ID WP_001094400.1
Coordinates 2661287..2661616 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag BWG_RS13225 Protein ID WP_000072690.1
Coordinates 2660949..2661266 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BWG_RS13205 2656001..2657010 - 1010 Protein_2524 arsenic transporter -
BWG_RS13210 (BWG_2395) 2657152..2658855 + 1704 WP_000896263.1 hypothetical protein -
BWG_RS24000 2659427..2659650 + 224 Protein_2526 DUF905 family protein -
BWG_RS13215 (BWG_2396) 2659753..2660211 + 459 WP_000211841.1 antirestriction protein -
BWG_RS13220 (BWG_2397) 2660220..2660702 + 483 WP_001407480.1 RadC family protein -
BWG_RS24005 (BWG_2398) 2660711..2660911 + 201 WP_001395452.1 DUF987 domain-containing protein -
BWG_RS13225 (BWG_2399) 2660949..2661266 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BWG_RS13230 (BWG_2400) 2661287..2661616 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
BWG_RS22980 (BWG_2401) 2661980..2666560 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T23866 WP_001094400.1 NC_012759:2661287-2661616 [Escherichia coli BW2952]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T23866 NC_012759:2661287-2661616 [Escherichia coli BW2952]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT23866 WP_000072690.1 NC_012759:2660949-2661266 [Escherichia coli BW2952]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT23866 NC_012759:2660949-2661266 [Escherichia coli BW2952]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References