238657

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 599184..599994 Replicon chromosome
Accession NZ_CP093465
Organism Klebsiella pneumoniae strain VA681

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag MO412_RS02880 Protein ID WP_002887280.1
Coordinates 599461..599994 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag MO412_RS02875 Protein ID WP_002887278.1
Coordinates 599184..599450 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO412_RS02855 (MO412_02855) 595056..595400 - 345 WP_002887266.1 cation efflux system protein CusF -
MO412_RS02860 (MO412_02860) 595418..596803 - 1386 WP_002887267.1 efflux transporter outer membrane subunit -
MO412_RS02865 (MO412_02865) 596975..597658 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
MO412_RS02870 (MO412_02870) 597648..599081 + 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
MO412_RS02875 (MO412_02875) 599184..599450 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
MO412_RS02880 (MO412_02880) 599461..599994 + 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
MO412_RS02885 (MO412_02885) 600042..601163 - 1122 WP_002887282.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T238657 WP_002887280.1 NZ_CP093465:599461-599994 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T238657 NZ_LR890426:c1536688-1536586 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT238657 WP_002887278.1 NZ_CP093465:599184-599450 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT238657 NZ_LR890426:1536579-1536724 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References