Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4616610..4617126 Replicon chromosome
Accession NZ_CP093458
Organism Klebsiella pneumoniae strain VA684

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag MO416_RS22315 Protein ID WP_004178374.1
Coordinates 4616610..4616894 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MO416_RS22320 Protein ID WP_002886901.1
Coordinates 4616884..4617126 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO416_RS22290 (MO416_22270) 4612027..4612290 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
MO416_RS22295 (MO416_22275) 4612420..4612593 + 174 WP_075394524.1 hypothetical protein -
MO416_RS22300 (MO416_22280) 4612596..4613339 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MO416_RS22305 (MO416_22285) 4613696..4615834 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MO416_RS22310 (MO416_22290) 4616142..4616606 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MO416_RS22315 (MO416_22295) 4616610..4616894 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MO416_RS22320 (MO416_22300) 4616884..4617126 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MO416_RS22325 (MO416_22305) 4617204..4619114 - 1911 WP_075394523.1 PRD domain-containing protein -
MO416_RS22330 (MO416_22310) 4619137..4620291 - 1155 WP_002886900.1 lactonase family protein -
MO416_RS22335 (MO416_22315) 4620358..4621098 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T238648 WP_004178374.1 NZ_CP093458:c4616894-4616610 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T238648 NZ_LR890424:3963234-3963452 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT238648 WP_002886901.1 NZ_CP093458:c4617126-4616884 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT238648 NZ_LR890424:3962833-3963207 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References