Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3896841..3897460 Replicon chromosome
Accession NZ_CP093458
Organism Klebsiella pneumoniae strain VA684

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MO416_RS18900 Protein ID WP_002892050.1
Coordinates 3897242..3897460 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MO416_RS18895 Protein ID WP_002892066.1
Coordinates 3896841..3897215 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO416_RS18885 (MO416_18870) 3891993..3893186 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MO416_RS18890 (MO416_18875) 3893209..3896355 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MO416_RS18895 (MO416_18880) 3896841..3897215 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MO416_RS18900 (MO416_18885) 3897242..3897460 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MO416_RS18905 (MO416_18890) 3897619..3898185 + 567 WP_002892030.1 maltose O-acetyltransferase -
MO416_RS18910 (MO416_18895) 3898157..3898297 - 141 WP_004147370.1 hypothetical protein -
MO416_RS18915 (MO416_18900) 3898318..3898788 + 471 WP_002892026.1 YlaC family protein -
MO416_RS18920 (MO416_18905) 3898763..3900214 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MO416_RS18925 (MO416_18910) 3900315..3901013 + 699 WP_002892021.1 GNAT family protein -
MO416_RS18930 (MO416_18915) 3901010..3901150 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MO416_RS18935 (MO416_18920) 3901150..3901413 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T238646 WP_002892050.1 NZ_CP093458:3897242-3897460 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T238646 NZ_LR890424:1939370-1939472 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT238646 WP_002892066.1 NZ_CP093458:3896841-3897215 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT238646 NZ_LR890424:c1939479-1939334 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References