Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2635758..2637346 Replicon chromosome
Accession NZ_CP093458
Organism Klebsiella pneumoniae strain VA684

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag MO416_RS12895 Protein ID WP_002904792.1
Coordinates 2635758..2637080 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MO416_RS12900 Protein ID WP_002904790.1
Coordinates 2637080..2637346 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO416_RS12880 (MO416_12875) 2630814..2633315 + 2502 WP_075394893.1 fimbria/pilus outer membrane usher protein -
MO416_RS12885 (MO416_12880) 2633303..2634307 + 1005 WP_009485243.1 fimbrial protein -
MO416_RS12890 (MO416_12885) 2634449..2635741 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MO416_RS12895 (MO416_12890) 2635758..2637080 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
MO416_RS12900 (MO416_12895) 2637080..2637346 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MO416_RS12905 (MO416_12900) 2637733..2638059 - 327 WP_004143476.1 hydroxyisourate hydrolase -
MO416_RS12910 (MO416_12905) 2638056..2638556 - 501 WP_040188216.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MO416_RS12915 (MO416_12910) 2638534..2639913 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
MO416_RS12920 (MO416_12915) 2640259..2641413 + 1155 WP_040188215.1 FAD-dependent urate hydroxylase HpxO -
MO416_RS12925 (MO416_12920) 2641394..2642317 - 924 WP_040188213.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T238644 WP_002904792.1 NZ_CP093458:c2637080-2635758 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T238644 NZ_LR890424:807029-807439 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT238644 WP_002904790.1 NZ_CP093458:c2637346-2637080 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT238644 NZ_LR890424:806782-807048 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References