Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837488..838145 Replicon chromosome
Accession NZ_CP093458
Organism Klebsiella pneumoniae strain VA684

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MO416_RS04180 Protein ID WP_002916310.1
Coordinates 837735..838145 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MO416_RS04175 Protein ID WP_002916312.1
Coordinates 837488..837754 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO416_RS04150 (MO416_04150) 832644..834077 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
MO416_RS04155 (MO416_04155) 834196..834924 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MO416_RS04160 (MO416_04160) 834974..835285 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MO416_RS04165 (MO416_04165) 835449..836108 + 660 WP_002916317.1 hemolysin III family protein -
MO416_RS04170 (MO416_04170) 836259..837242 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MO416_RS04175 (MO416_04175) 837488..837754 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MO416_RS04180 (MO416_04180) 837735..838145 + 411 WP_002916310.1 protein YgfX Toxin
MO416_RS04185 (MO416_04185) 838152..838673 - 522 WP_004144730.1 flavodoxin FldB -
MO416_RS04190 (MO416_04190) 838774..839670 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MO416_RS04195 (MO416_04195) 839693..840406 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MO416_RS04200 (MO416_04200) 840412..842145 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T238635 WP_002916310.1 NZ_CP093458:837735-838145 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T238635 NZ_LR890422:1949643-1949745 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT238635 WP_002916312.1 NZ_CP093458:837488-837754 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238635 NZ_LR890422:c1949752-1949607 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References