Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2539..3182 Replicon plasmid pVA833-45
Accession NZ_CP093452
Organism Klebsiella pneumoniae strain VA833

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag MO408_RS26900 Protein ID WP_000754566.1
Coordinates 2539..2955 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag MO408_RS26905 Protein ID WP_001261276.1
Coordinates 2952..3182 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO408_RS26880 (MO408_26855) 46..543 - 498 WP_283544529.1 hypothetical protein -
MO408_RS26885 (MO408_26860) 552..974 - 423 WP_032446862.1 hypothetical protein -
MO408_RS26890 (MO408_26865) 997..1197 - 201 Protein_2 transposase -
MO408_RS26895 (MO408_26870) 1479..2335 - 857 Protein_3 IS3-like element ISEc15 family transposase -
MO408_RS26900 (MO408_26875) 2539..2955 - 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
MO408_RS26905 (MO408_26880) 2952..3182 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MO408_RS26910 (MO408_26885) 3756..4106 + 351 WP_000493378.1 hypothetical protein -
MO408_RS26915 (MO408_26890) 4157..4900 + 744 WP_000129823.1 hypothetical protein -
MO408_RS26920 (MO408_26895) 4897..5673 + 777 WP_000015958.1 site-specific integrase -
MO408_RS26925 (MO408_26900) 5731..5988 - 258 WP_000764642.1 hypothetical protein -
MO408_RS26930 (MO408_26905) 6117..6220 - 104 Protein_10 hypothetical protein -
MO408_RS26935 (MO408_26910) 6750..7616 + 867 WP_004118283.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qacE / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 - 1..44806 44806


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T238630 WP_000754566.1 NZ_CP093452:c2955-2539 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

>T238630 NZ_LR890417:21888-22193 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT238630 WP_001261276.1 NZ_CP093452:c3182-2952 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT238630 NZ_LR890417:21668-21886 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References