Detailed information of TA system TA238627

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5017005..5017806
• Replicon: chromosome
• Accession: NZ_CP093451
• Organism: Klebsiella pneumoniae strain VA833

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MO408_RS24810
• Protein ID: WP_064143481.1
• Coordinates: 5017429..5017806 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: MO408_RS24805
• Protein ID: WP_064143482.1
• Coordinates: 5017005..5017382 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO408_RS24780 (5014430)	5014430..5014663	+	234	WP_001117568.1	DUF905 family protein	-
MO408_RS24785 (5014754)	5014754..5015572	+	819	WP_001610805.1	DUF932 domain-containing protein	-
MO408_RS24790 (5015664)	5015664..5016149	+	486	WP_000214414.1	antirestriction protein	-
MO408_RS24795 (5016165)	5016165..5016641	+	477	WP_110225547.1	RadC family protein	-
MO408_RS24800 (5016704)	5016704..5016925	+	222	WP_110225546.1	DUF987 domain-containing protein	-
MO408_RS24805 (5017005)	5017005..5017382	+	378	WP_064143482.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MO408_RS24810 (5017429)	5017429..5017806	+	378	WP_064143481.1	TA system toxin CbtA family protein	Toxin
MO408_RS24815 (5017803)	5017803..5018000	+	198	Protein_4866	DUF5983 family protein	-
MO408_RS24820 (5018028)	5018028..5018225	+	198	WP_023563519.1	DUF957 domain-containing protein	-
MO408_RS24825 (5018310)	5018310..5019152	+	843	WP_064143480.1	DUF4942 domain-containing protein	-
MO408_RS24835 (5021245)	5021245..5021535	-	291	WP_004153693.1	PerC family transcriptional regulator	-
MO408_RS24840 (5021730)	5021730..5021852	+	123	WP_004146686.1	hypothetical protein	-
MO408_RS24845 (5021847)	5021847..5022413	-	567	WP_002885396.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5002019..5022425	20406

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14037.93 Da
• Isoelectric Point: 7.2922

>T238627 WP_064143481.1 NZ_CP093451:5017429-5017806 [Klebsiella pneumoniae]
MKTLPDTHEREASRCSSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCAHSQLINSIDILRARRATGLLTRSNYRTVNDIIRGKDAEAKQ

Nucleotide

• Length: 378 bp

>T238627 NZ_LR890415:c5188703-5188320 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13751.48 Da
• Isoelectric Point: 5.4906

>AT238627 WP_064143482.1 NZ_CP093451:5017005-5017382 [Klebsiella pneumoniae]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Nucleotide

• Length: 378 bp

>AT238627 NZ_LR890415:c5188945-5188703 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA