Detailed information of TA system TA238623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2836629..2838217
• Replicon: chromosome
• Accession: NZ_CP093451
• Organism: Klebsiella pneumoniae strain VA833

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MO408_RS14200
• Protein ID: WP_032436337.1
• Coordinates: 2836629..2837951 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: MO408_RS14205
• Protein ID: WP_002904790.1
• Coordinates: 2837951..2838217 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO408_RS14185 (2831686)	2831686..2834187	+	2502	WP_087836359.1	fimbria/pilus outer membrane usher protein	-
MO408_RS14190 (2834175)	2834175..2835179	+	1005	WP_032436338.1	fimbrial protein	-
MO408_RS14195 (2835320)	2835320..2836612	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MO408_RS14200 (2836629)	2836629..2837951	-	1323	WP_032436337.1	type II toxin-antitoxin system HipA family toxin	Toxin
MO408_RS14205 (2837951)	2837951..2838217	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MO408_RS14210 (2838604)	2838604..2838930	-	327	WP_032436336.1	hydroxyisourate hydrolase	-
MO408_RS14215 (2838927)	2838927..2839427	-	501	WP_032436335.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MO408_RS14220 (2839405)	2839405..2840784	-	1380	Protein_2789	nucleobase:cation symporter-2 family protein	-
MO408_RS14225 (2841130)	2841130..2842284	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MO408_RS14230 (2842265)	2842265..2843188	-	924	WP_032436334.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49106.39 Da
• Isoelectric Point: 7.5617

>T238623 WP_032436337.1 NZ_CP093451:c2837951-2836629 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T238623 NZ_LR890415:4036441-4036659 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT238623 WP_002904790.1 NZ_CP093451:c2838217-2837951 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT238623 NZ_LR890415:4036040-4036414 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8