Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 830280..830937 Replicon chromosome
Accession NZ_CP093451
Organism Klebsiella pneumoniae strain VA833

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MO408_RS04135 Protein ID WP_002916310.1
Coordinates 830527..830937 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MO408_RS04130 Protein ID WP_002916312.1
Coordinates 830280..830546 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO408_RS04105 (825488) 825488..826921 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MO408_RS04110 (827040) 827040..827768 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MO408_RS04115 (827818) 827818..828129 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MO408_RS04120 (828293) 828293..828952 + 660 WP_002916317.1 hemolysin III family protein -
MO408_RS04125 (829051) 829051..830034 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
MO408_RS04130 (830280) 830280..830546 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MO408_RS04135 (830527) 830527..830937 + 411 WP_002916310.1 protein YgfX Toxin
MO408_RS04140 (830944) 830944..831465 - 522 WP_004144730.1 flavodoxin FldB -
MO408_RS04145 (831566) 831566..832462 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MO408_RS04150 (832485) 832485..833198 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MO408_RS04155 (833204) 833204..834937 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T238614 WP_002916310.1 NZ_CP093451:830527-830937 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T238614 NZ_LR890411:40403-40819 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT238614 WP_002916312.1 NZ_CP093451:830280-830546 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238614 NZ_LR890411:40176-40406 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References