Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4454953..4455734 | Replicon | chromosome |
| Accession | NZ_CP093445 | ||
| Organism | Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A744KWD4 |
| Locus tag | MOV10_RS21605 | Protein ID | WP_023221226.1 |
| Coordinates | 4454953..4455444 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | - |
| Locus tag | MOV10_RS21610 | Protein ID | WP_094894228.1 |
| Coordinates | 4455441..4455734 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOV10_RS21580 (4450089) | 4450089..4452527 | - | 2439 | WP_242105484.1 | F4 (K88) fimbrial usher FaeD | - |
| MOV10_RS21585 (4452537) | 4452537..4453076 | - | 540 | WP_000721295.1 | type 1 fimbrial protein | - |
| MOV10_RS21590 (4453111) | 4453111..4453401 | - | 291 | WP_000773469.1 | PapB/FocB family fimbrial expression transcriptional regulator | - |
| MOV10_RS21595 (4453988) | 4453988..4454215 | + | 228 | WP_001112992.1 | hypothetical protein | - |
| MOV10_RS21600 (4454490) | 4454490..4454738 | - | 249 | Protein_4230 | IS481 family transposase | - |
| MOV10_RS21605 (4454953) | 4454953..4455444 | - | 492 | WP_023221226.1 | GNAT family N-acetyltransferase | Toxin |
| MOV10_RS21610 (4455441) | 4455441..4455734 | - | 294 | WP_094894228.1 | DUF1778 domain-containing protein | Antitoxin |
| MOV10_RS21615 (4456052) | 4456052..4456273 | + | 222 | WP_001595143.1 | hypothetical protein | - |
| MOV10_RS21620 (4456539) | 4456539..4457414 | + | 876 | WP_023195838.1 | AraC family transcriptional regulator | - |
| MOV10_RS21625 (4457411) | 4457411..4457698 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| MOV10_RS21630 (4457691) | 4457691..4457999 | - | 309 | WP_139775665.1 | ATP-binding cassette domain-containing protein | - |
| MOV10_RS21635 (4457998) | 4457998..4458372 | + | 375 | WP_239822698.1 | Ig-like domain-containing protein | - |
| MOV10_RS21640 (4458668) | 4458668..4459573 | - | 906 | WP_080073557.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | faeI / faeH / faeF / faeE / faeD / faeC | 4432484..4458372 | 25888 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17637.44 Da Isoelectric Point: 7.7297
>T238609 WP_023221226.1 NZ_CP093445:c4455444-4454953 [Salmonella enterica subsp. enterica serovar Abeokuta]
MISTPEPLHAGHILTSFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTSFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T238609 NZ_LR890410:3872746-3873144 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10964.62 Da Isoelectric Point: 9.8590
>AT238609 WP_094894228.1 NZ_CP093445:c4455734-4455441 [Salmonella enterica subsp. enterica serovar Abeokuta]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTLAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTLAPWEQEK
Download Length: 294 bp
>AT238609 NZ_LR890410:3872450-3872743 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|