Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4299719..4300362 Replicon chromosome
Accession NZ_CP093445
Organism Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MOV10_RS20805 Protein ID WP_000048134.1
Coordinates 4299946..4300362 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MOV10_RS20800 Protein ID WP_001261294.1
Coordinates 4299719..4299949 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV10_RS20790 (4296733) 4296733..4298871 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
MOV10_RS20795 (4299088) 4299088..4299552 + 465 WP_076736138.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOV10_RS20800 (4299719) 4299719..4299949 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MOV10_RS20805 (4299946) 4299946..4300362 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MOV10_RS20810 (4300423) 4300423..4302336 - 1914 WP_064013343.1 BglG family transcription antiterminator -
MOV10_RS20815 (4302353) 4302353..4303093 - 741 WP_242105458.1 KDGP aldolase family protein -
MOV10_RS20820 (4303090) 4303090..4304208 - 1119 WP_058820892.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOV10_RS20825 (4304192) 4304192..4305325 - 1134 WP_242105459.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T238608 WP_000048134.1 NZ_CP093445:4299946-4300362 [Salmonella enterica subsp. enterica serovar Abeokuta]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T238608 NZ_LR890410:3597798-3598112 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT238608 WP_001261294.1 NZ_CP093445:4299719-4299949 [Salmonella enterica subsp. enterica serovar Abeokuta]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT238608 NZ_LR890410:3597562-3597795 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References