Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yeeU/CbtA-CbeA |
| Location | 3731598..3732336 | Replicon | chromosome |
| Accession | NZ_CP093445 | ||
| Organism | Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | MOV10_RS18225 | Protein ID | WP_242105328.1 |
| Coordinates | 3731983..3732336 (+) | Length | 118 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | MOV10_RS18220 | Protein ID | WP_242105327.1 |
| Coordinates | 3731598..3731939 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOV10_RS18170 (3726604) | 3726604..3726897 | + | 294 | WP_023203339.1 | hypothetical protein | - |
| MOV10_RS18175 (3727251) | 3727251..3727964 | + | 714 | WP_242105319.1 | WYL domain-containing protein | - |
| MOV10_RS18180 (3728037) | 3728037..3728183 | + | 147 | WP_023892166.1 | hypothetical protein | - |
| MOV10_RS18185 (3728200) | 3728200..3728403 | + | 204 | WP_242105320.1 | transposase | - |
| MOV10_RS18190 (3728468) | 3728468..3729382 | + | 915 | WP_242105322.1 | inhibitor of vertebrate lysozyme family protein | - |
| MOV10_RS18195 (3729457) | 3729457..3729690 | + | 234 | WP_242105323.1 | DUF905 domain-containing protein | - |
| MOV10_RS18200 (3729687) | 3729687..3729917 | + | 231 | WP_242105325.1 | hypothetical protein | - |
| MOV10_RS18205 (3730023) | 3730023..3730844 | + | 822 | WP_242106192.1 | DUF932 domain-containing protein | - |
| MOV10_RS18210 (3730857) | 3730857..3731357 | + | 501 | WP_064034372.1 | DNA repair protein RadC | - |
| MOV10_RS18215 (3731354) | 3731354..3731575 | + | 222 | WP_023242230.1 | DUF987 family protein | - |
| MOV10_RS18220 (3731598) | 3731598..3731939 | + | 342 | WP_242105327.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MOV10_RS18225 (3731983) | 3731983..3732336 | + | 354 | WP_242105328.1 | TA system toxin CbtA family protein | Toxin |
| MOV10_RS18230 (3732430) | 3732430..3733633 | + | 1204 | Protein_3573 | AAA family ATPase | - |
| MOV10_RS18235 (3733618) | 3733618..3733839 | + | 222 | WP_127836141.1 | hypothetical protein | - |
| MOV10_RS18240 (3733836) | 3733836..3734561 | + | 726 | WP_242105329.1 | retron system putative HNH endonuclease | - |
| MOV10_RS18245 (3734710) | 3734710..3735543 | + | 834 | WP_242105330.1 | DUF4942 domain-containing protein | - |
| MOV10_RS18255 (3736023) | 3736023..3737273 | - | 1251 | WP_000893225.1 | glutamate-5-semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3702585..3735543 | 32958 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13464.40 Da Isoelectric Point: 9.0562
>T238604 WP_242105328.1 NZ_CP093445:3731983-3732336 [Salmonella enterica subsp. enterica serovar Abeokuta]
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLINQCKKRKCNQPDG
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLINQCKKRKCNQPDG
Download Length: 354 bp
>T238604 NZ_LR890410:c3185739-3185365 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12923.66 Da Isoelectric Point: 6.4663
>AT238604 WP_242105327.1 NZ_CP093445:3731598-3731939 [Salmonella enterica subsp. enterica serovar Abeokuta]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNRLHYLDDRAGIYGEFTPAQLQTLDIVFPMFIKHMEAALRTGALNPREAR
RFMTELRGITYEADTRGSFGYVYLSLYPTVVKN
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNRLHYLDDRAGIYGEFTPAQLQTLDIVFPMFIKHMEAALRTGALNPREAR
RFMTELRGITYEADTRGSFGYVYLSLYPTVVKN
Download Length: 342 bp
>AT238604 NZ_LR890410:c3186197-3185829 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|