Detailed information of TA system TA238603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3558264..3558884
• Replicon: chromosome
• Accession: NZ_CP093445
• Organism: Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: MOV10_RS17380
• Protein ID: WP_001280991.1
• Coordinates: 3558666..3558884 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: MOV10_RS17375
• Protein ID: WP_000344807.1
• Coordinates: 3558264..3558638 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV10_RS17365 (3553403)	3553403..3554596	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
MOV10_RS17370 (3554619)	3554619..3557768	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
MOV10_RS17375 (3558264)	3558264..3558638	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
MOV10_RS17380 (3558666)	3558666..3558884	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
MOV10_RS17385 (3559063)	3559063..3559614	+	552	WP_001278793.1	maltose O-acetyltransferase	-
MOV10_RS17390 (3559732)	3559732..3560202	+	471	WP_000136183.1	YlaC family protein	-
MOV10_RS17395 (3560258)	3560258..3560398	-	141	WP_242105284.1	type B 50S ribosomal protein L36	-
MOV10_RS17400 (3560404)	3560404..3560664	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
MOV10_RS17405 (3560889)	3560889..3562439	+	1551	WP_000213145.1	EAL domain-containing protein	-
MOV10_RS17415 (3562670)	3562670..3563059	+	390	WP_000961285.1	MGMT family protein	-
MOV10_RS17420 (3563092)	3563092..3563661	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T238603 WP_001280991.1 NZ_CP093445:3558666-3558884 [Salmonella enterica subsp. enterica serovar Abeokuta]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T238603 NZ_LR890410:3174229-3174402 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT238603 WP_000344807.1 NZ_CP093445:3558264-3558638 [Salmonella enterica subsp. enterica serovar Abeokuta]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT238603 NZ_LR890410:3173905-3174201 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0