Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3558264..3558884 Replicon chromosome
Accession NZ_CP093445
Organism Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOV10_RS17380 Protein ID WP_001280991.1
Coordinates 3558666..3558884 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOV10_RS17375 Protein ID WP_000344807.1
Coordinates 3558264..3558638 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV10_RS17365 (3553403) 3553403..3554596 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOV10_RS17370 (3554619) 3554619..3557768 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MOV10_RS17375 (3558264) 3558264..3558638 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOV10_RS17380 (3558666) 3558666..3558884 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOV10_RS17385 (3559063) 3559063..3559614 + 552 WP_001278793.1 maltose O-acetyltransferase -
MOV10_RS17390 (3559732) 3559732..3560202 + 471 WP_000136183.1 YlaC family protein -
MOV10_RS17395 (3560258) 3560258..3560398 - 141 WP_242105284.1 type B 50S ribosomal protein L36 -
MOV10_RS17400 (3560404) 3560404..3560664 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MOV10_RS17405 (3560889) 3560889..3562439 + 1551 WP_000213145.1 EAL domain-containing protein -
MOV10_RS17415 (3562670) 3562670..3563059 + 390 WP_000961285.1 MGMT family protein -
MOV10_RS17420 (3563092) 3563092..3563661 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238603 WP_001280991.1 NZ_CP093445:3558666-3558884 [Salmonella enterica subsp. enterica serovar Abeokuta]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238603 NZ_LR890410:3174229-3174402 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238603 WP_000344807.1 NZ_CP093445:3558264-3558638 [Salmonella enterica subsp. enterica serovar Abeokuta]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238603 NZ_LR890410:3173905-3174201 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References