238602

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2441321..2441843 Replicon chromosome
Accession NZ_CP093445
Organism Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MOV10_RS11810 Protein ID WP_000221343.1
Coordinates 2441559..2441843 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MOV10_RS11805 Protein ID WP_000885424.1
Coordinates 2441321..2441569 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV10_RS11785 (2436892) 2436892..2438403 - 1512 WP_094913431.1 FGGY family carbohydrate kinase -
MOV10_RS11790 (2438481) 2438481..2439872 - 1392 WP_023218026.1 PTS galactitol transporter subunit IIC -
MOV10_RS11795 (2439884) 2439884..2440165 - 282 WP_023218025.1 PTS sugar transporter subunit IIB -
MOV10_RS11800 (2440225) 2440225..2440689 - 465 WP_072275481.1 PTS sugar transporter subunit IIA -
MOV10_RS11805 (2441321) 2441321..2441569 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOV10_RS11810 (2441559) 2441559..2441843 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOV10_RS11815 (2442014) 2442014..2442403 + 390 WP_131041341.1 RidA family protein -
MOV10_RS11820 (2442461) 2442461..2443534 - 1074 WP_242106132.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MOV10_RS11825 (2443727) 2443727..2444215 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
MOV10_RS11830 (2444260) 2444260..2445768 + 1509 WP_242106133.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2425136..2448625 23489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T238602 WP_000221343.1 NZ_CP093445:2441559-2441843 [Salmonella enterica subsp. enterica serovar Abeokuta]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T238602 NZ_LR890410:2875733-2876044 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT238602 WP_000885424.1 NZ_CP093445:2441321-2441569 [Salmonella enterica subsp. enterica serovar Abeokuta]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT238602 NZ_LR890410:2876045-2876335 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References