Detailed information of TA system TA238593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 1977295..1977935
• Replicon: chromosome
• Accession: NZ_CP093445
• Organism: Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MOV10_RS09490
• Protein ID: WP_242106157.1
• Coordinates: 1977295..1977471 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MOV10_RS09495
• Protein ID: WP_080191154.1
• Coordinates: 1977519..1977935 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV10_RS09465 (1972396)	1972396..1973712	+	1317	WP_242105972.1	DNA cytosine methyltransferase	-
MOV10_RS09470 (1973712)	1973712..1974314	+	603	WP_242106155.1	hypothetical protein	-
MOV10_RS09475 (1974579)	1974579..1975172	+	594	WP_242105974.1	Rha family transcriptional regulator	-
MOV10_RS09480 (1975201)	1975201..1976106	-	906	WP_242105976.1	hypothetical protein	-
MOV10_RS09485 (1976027)	1976027..1976872	-	846	WP_242105979.1	CRISPR-associated endonuclease Cas1	-
MOV10_RS09490 (1977295)	1977295..1977471	+	177	WP_242106157.1	type II toxin-antitoxin system HicA family toxin	Toxin
MOV10_RS09495 (1977519)	1977519..1977935	+	417	WP_080191154.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MOV10_RS09500 (1978219)	1978219..1978494	-	276	WP_242105981.1	DUF1456 family protein	-
MOV10_RS09505 (1978495)	1978495..1978896	-	402	WP_242105983.1	hypothetical protein	-
MOV10_RS09510 (1978893)	1978893..1979153	-	261	WP_242105985.1	hypothetical protein	-
MOV10_RS09515 (1979190)	1979190..1979411	-	222	WP_242105986.1	hypothetical protein	-
MOV10_RS09520 (1979424)	1979424..1979759	-	336	WP_242105987.1	hypothetical protein	-
MOV10_RS09525 (1980058)	1980058..1980363	+	306	WP_242105988.1	phage holin family protein	-
MOV10_RS09530 (1980372)	1980372..1980521	+	150	WP_165901240.1	hypothetical protein	-
MOV10_RS09535 (1980582)	1980582..1981007	+	426	WP_242105989.1	lysozyme	-
MOV10_RS09540 (1981336)	1981336..1981869	+	534	WP_031605576.1	KilA-N domain-containing protein	-
MOV10_RS09545 (1981899)	1981899..1982090	+	192	WP_242105990.1	hypothetical protein	-
MOV10_RS09550 (1982211)	1982211..1982408	+	198	WP_183074519.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliA	1949305..2002683	53378

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (82-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6737.76 Da
• Isoelectric Point: 11.2510

>T238593 WP_242106157.1 NZ_CP093445:1977295-1977471 [Salmonella enterica subsp. enterica serovar Abeokuta]
VKQGEFRRWLESQGVEVSNGTNHLKLRYNGKRSVMPRHPGDEIKEPLRRAILKQLGLN

Nucleotide

• Length: 177 bp

>T238593 NZ_LR890410:c548709-548607 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15229.35 Da
• Isoelectric Point: 4.2530

>AT238593 WP_080191154.1 NZ_CP093445:1977519-1977935 [Salmonella enterica subsp. enterica serovar Abeokuta]
MRYPLNLVPAPEGGYVVTFPDIPEALTQGDTREEALSAALDALVTAFEFYFEDNEQIPLPSEVNAGDDFVEVPLSVASKV
LLLNAFLESRLTQQELAKRIGKPRQEITRLFDLNHATKIDAVQSAAKALGRELTLNIM

Nucleotide

• Length: 417 bp

>AT238593 NZ_LR890410:548569-548837 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT