Detailed information of TA system TA238590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 314057..314643
• Replicon: chromosome
• Accession: NZ_CP093445
• Organism: Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)

• Gene name: doc
• Uniprot ID: Q57IR9
• Locus tag: MOV10_RS01450
• Protein ID: WP_000174963.1
• Coordinates: 314275..314643 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: M7SDJ3
• Locus tag: MOV10_RS01445
• Protein ID: WP_001520924.1
• Coordinates: 314057..314278 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV10_RS01420 (309077)	309077..310186	+	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
MOV10_RS01425 (310246)	310246..311172	+	927	WP_000003005.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
MOV10_RS01430 (311169)	311169..312446	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
MOV10_RS01435 (312443)	312443..313210	+	768	WP_000082083.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
MOV10_RS01440 (313212)	313212..313925	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
MOV10_RS01445 (314057)	314057..314278	+	222	WP_001520924.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MOV10_RS01450 (314275)	314275..314643	+	369	WP_000174963.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
MOV10_RS01455 (314902)	314902..316218	+	1317	WP_000624747.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
MOV10_RS01460 (316323)	316323..317210	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
MOV10_RS01465 (317207)	317207..318052	+	846	WP_000572203.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
MOV10_RS01470 (318055)	318055..319125	+	1071	WP_000907838.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	311169..319862	8693

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13573.85 Da
• Isoelectric Point: 6.7252

>T238590 WP_000174963.1 NZ_CP093445:314275-314643 [Salmonella enterica subsp. enterica serovar Abeokuta]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T238590 NZ_LR890406:c29781-29476 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8152.14 Da
• Isoelectric Point: 5.0775

>AT238590 WP_001520924.1 NZ_CP093445:314057-314278 [Salmonella enterica subsp. enterica serovar Abeokuta]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT238590 NZ_LR890406:c30001-29783 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A5H6KCD5

Antitoxin

• AlphaFold DB: A0A6C6Z871