Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204314..205074 Replicon chromosome
Accession NZ_CP093445
Organism Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag MOV10_RS00950 Protein ID WP_000533909.1
Coordinates 204589..205074 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag MOV10_RS00945 Protein ID WP_000965889.1
Coordinates 204314..204601 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV10_RS00930 (199736) 199736..201805 + 2070 WP_242105593.1 glycine--tRNA ligase subunit beta -
MOV10_RS00935 (202268) 202268..202699 + 432 Protein_186 IS3 family transposase -
MOV10_RS00940 (203063) 203063..203968 + 906 WP_183056899.1 hypothetical protein -
MOV10_RS00945 (204314) 204314..204601 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
MOV10_RS00950 (204589) 204589..205074 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
MOV10_RS00955 (205445) 205445..205984 - 540 WP_242105595.1 copper-binding periplasmic metallochaperone CueP -
MOV10_RS00960 (206158) 206158..206370 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MOV10_RS00965 (206658) 206658..206948 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MOV10_RS00970 (207387) 207387..208097 + 711 WP_023138209.1 DUF3053 domain-containing protein -
MOV10_RS00975 (208147) 208147..209121 - 975 WP_000804681.1 glyoxylate/hydroxypyruvate reductase GhrB -
MOV10_RS00980 (209351) 209351..210013 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T238589 WP_000533909.1 NZ_CP093445:204589-205074 [Salmonella enterica subsp. enterica serovar Abeokuta]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T238589 NZ_LR890405:c4709250-4709077 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT238589 WP_000965889.1 NZ_CP093445:204314-204601 [Salmonella enterica subsp. enterica serovar Abeokuta]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT238589 NZ_LR890405:c4709574-4709278 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References