Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 204314..205074 | Replicon | chromosome |
Accession | NZ_CP093445 | ||
Organism | Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | Q57IH1 |
Locus tag | MOV10_RS00950 | Protein ID | WP_000533909.1 |
Coordinates | 204589..205074 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | Q8Z2B2 |
Locus tag | MOV10_RS00945 | Protein ID | WP_000965889.1 |
Coordinates | 204314..204601 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MOV10_RS00930 (199736) | 199736..201805 | + | 2070 | WP_242105593.1 | glycine--tRNA ligase subunit beta | - |
MOV10_RS00935 (202268) | 202268..202699 | + | 432 | Protein_186 | IS3 family transposase | - |
MOV10_RS00940 (203063) | 203063..203968 | + | 906 | WP_183056899.1 | hypothetical protein | - |
MOV10_RS00945 (204314) | 204314..204601 | + | 288 | WP_000965889.1 | DUF1778 domain-containing protein | Antitoxin |
MOV10_RS00950 (204589) | 204589..205074 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
MOV10_RS00955 (205445) | 205445..205984 | - | 540 | WP_242105595.1 | copper-binding periplasmic metallochaperone CueP | - |
MOV10_RS00960 (206158) | 206158..206370 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
MOV10_RS00965 (206658) | 206658..206948 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
MOV10_RS00970 (207387) | 207387..208097 | + | 711 | WP_023138209.1 | DUF3053 domain-containing protein | - |
MOV10_RS00975 (208147) | 208147..209121 | - | 975 | WP_000804681.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
MOV10_RS00980 (209351) | 209351..210013 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T238589 WP_000533909.1 NZ_CP093445:204589-205074 [Salmonella enterica subsp. enterica serovar Abeokuta]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T238589 NZ_LR890405:c4709250-4709077 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10964.59 Da Isoelectric Point: 4.6811
>AT238589 WP_000965889.1 NZ_CP093445:204314-204601 [Salmonella enterica subsp. enterica serovar Abeokuta]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT238589 NZ_LR890405:c4709574-4709278 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 7F36 | |
PDB | 7AK8 | |
PDB | 5FVJ |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A752RW74 |