Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4119018..4119571 Replicon chromosome
Accession NZ_CP093443
Organism Brevibacterium spongiae strain WHS-Z9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L1F31_RS18440 Protein ID WP_265418669.1
Coordinates 4119018..4119377 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L1F31_RS18445 Protein ID WP_265418670.1
Coordinates 4119374..4119571 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F31_RS18420 (L1F31_18395) 4114962..4116344 - 1383 WP_265418665.1 ABC transporter permease -
L1F31_RS18425 (L1F31_18400) 4116356..4117711 - 1356 WP_265418666.1 flagellar hook-associated protein -
L1F31_RS18430 (L1F31_18405) 4117711..4118448 - 738 WP_265418667.1 ABC transporter ATP-binding protein -
L1F31_RS18435 (L1F31_18410) 4118621..4119010 + 390 WP_265418668.1 VOC family protein -
L1F31_RS18440 (L1F31_18415) 4119018..4119377 - 360 WP_265418669.1 type II toxin-antitoxin system VapC family toxin Toxin
L1F31_RS18445 (L1F31_18420) 4119374..4119571 - 198 WP_265418670.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L1F31_RS18450 (L1F31_18425) 4119909..4121792 + 1884 WP_265418672.1 FAD-dependent monooxygenase -
L1F31_RS18455 (L1F31_18430) 4121854..4123170 - 1317 WP_265418673.1 DUF445 domain-containing protein -
L1F31_RS18460 (L1F31_18435) 4123411..4124235 + 825 WP_265418674.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13507.42 Da        Isoelectric Point: 5.5123

>T238588 WP_265418669.1 NZ_CP093443:c4119377-4119018 [Brevibacterium spongiae]
MILVDTSVWIDHLHQRDEELVRRLEDGAVGSHSAVIEELALGSIRSREEVLSSLEDLFRFPTLTHEELMFLISSHSLWGR
GLSVADTHLLGSVMLIEGALLWTRDKRLRRAAEELGRAH

Download         Length: 360 bp

>T238588 NZ_LR890405:4694495-4694872 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7035.95 Da        Isoelectric Point: 6.2912

>AT238588 WP_265418670.1 NZ_CP093443:c4119571-4119374 [Brevibacterium spongiae]
MRTTVTVDDELIAKATELSGITERSALIREALKTLVRVESSRRLAALGGTDPDSSAPPRRRDDVA

Download         Length: 198 bp

>AT238588 NZ_LR890405:4694074-4694448 [Escherichia coli]
GTGTCAGACACACCCCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACTCCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References