Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1825195..1825811 Replicon chromosome
Accession NZ_CP093428
Organism Pseudomonas migulae strain 8R6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MOQ58_RS08365 Protein ID WP_280163306.1
Coordinates 1825195..1825407 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MOQ58_RS08370 Protein ID WP_192226071.1
Coordinates 1825407..1825811 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ58_RS08330 (MOQ58_08315) 1820620..1821093 + 474 WP_192419640.1 cytochrome c-type biogenesis protein CcmH -
MOQ58_RS08335 (MOQ58_08320) 1821086..1822288 + 1203 WP_008039841.1 c-type cytochrome biogenesis protein CcmI -
MOQ58_RS08340 (MOQ58_08325) 1822303..1822707 + 405 WP_008026806.1 hypothetical protein -
MOQ58_RS08345 (MOQ58_08330) 1822764..1823339 - 576 WP_280163304.1 PIN domain-containing protein -
MOQ58_RS08350 (MOQ58_08335) 1823336..1823803 - 468 WP_280163305.1 helix-turn-helix domain-containing protein -
MOQ58_RS08355 (MOQ58_08340) 1823885..1824154 - 270 Protein_1645 LysR substrate-binding domain-containing protein -
MOQ58_RS08360 (MOQ58_08345) 1824194..1824913 - 720 WP_008026798.1 SDR family oxidoreductase -
MOQ58_RS08365 (MOQ58_08350) 1825195..1825407 + 213 WP_280163306.1 type II toxin-antitoxin system HicA family toxin Toxin
MOQ58_RS08370 (MOQ58_08355) 1825407..1825811 + 405 WP_192226071.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MOQ58_RS08375 (MOQ58_08360) 1825924..1827129 - 1206 WP_280163307.1 MFS transporter -
MOQ58_RS08380 (MOQ58_08365) 1827344..1827961 + 618 WP_253402296.1 hypothetical protein -
MOQ58_RS08385 (MOQ58_08370) 1828140..1829135 - 996 WP_280163308.1 sulfate ABC transporter substrate-binding protein -
MOQ58_RS08390 (MOQ58_08375) 1829229..1830053 - 825 WP_192226077.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7887.03 Da        Isoelectric Point: 10.3517

>T238586 WP_280163306.1 NZ_CP093428:1825195-1825407 [Pseudomonas migulae]
VQSRLLIKELQEAGWTLDRITGSHHLFTHRYNPYTIPVPHPKKDLPTGTVKSIRRRAGLYCPPASHAGDS

Download         Length: 213 bp

>T238586 NZ_LR890405:4384902-4385243 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14763.74 Da        Isoelectric Point: 4.3841

>AT238586 WP_192226071.1 NZ_CP093428:1825407-1825811 [Pseudomonas migulae]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAIEIAHIMLQELAADGESIPMPTSAAAHRGNPDFADMGWGM
LELDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp

>AT238586 NZ_LR890405:c4384907-4384831 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References