Detailed information of TA system TA238582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 250354..250997
• Replicon: chromosome
• Accession: NZ_CP093428
• Organism: Pseudomonas migulae strain 8R6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MOQ58_RS01130
• Protein ID: WP_280162655.1
• Coordinates: 250354..250536 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MOQ58_RS01135
• Protein ID: WP_032829017.1
• Coordinates: 250596..250997 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ58_RS01100 (MOQ58_01100)	246173..246433	-	261	WP_008032471.1	hypothetical protein	-
MOQ58_RS01105 (MOQ58_01105)	246456..246923	-	468	WP_223554301.1	DoxX family membrane protein	-
MOQ58_RS01110 (MOQ58_01110)	246999..247895	-	897	WP_223554298.1	SDR family oxidoreductase	-
MOQ58_RS01115 (MOQ58_01115)	247926..248432	-	507	WP_280162653.1	DUF1097 domain-containing protein	-
MOQ58_RS01120 (MOQ58_01120)	248464..249204	-	741	WP_280162654.1	SDR family oxidoreductase	-
MOQ58_RS01125 (MOQ58_01125)	249333..250223	+	891	WP_008032272.1	LysR family transcriptional regulator	-
MOQ58_RS01130 (MOQ58_01130)	250354..250536	+	183	WP_280162655.1	type II toxin-antitoxin system HicA family toxin	Toxin
MOQ58_RS01135 (MOQ58_01135)	250596..250997	+	402	WP_032829017.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MOQ58_RS01140 (MOQ58_01140)	251157..252194	+	1038	WP_280162656.1	L-glyceraldehyde 3-phosphate reductase	-
MOQ58_RS01145 (MOQ58_01145)	252363..253205	-	843	WP_280162657.1	taurine dioxygenase	-
MOQ58_RS01150 (MOQ58_01150)	253261..254094	-	834	WP_008032267.1	taurine ABC transporter permease TauC	-
MOQ58_RS01155 (MOQ58_01155)	254091..254885	-	795	WP_280162658.1	taurine ABC transporter ATP-binding subunit	-
MOQ58_RS01160 (MOQ58_01160)	254902..255879	-	978	WP_280162659.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6903.07 Da
• Isoelectric Point: 10.6720

>T238582 WP_280162655.1 NZ_CP093428:250354-250536 [Pseudomonas migulae]
MRSREMIRMIEEGGWYLVAVRGSHHQYKHLYKAGRVTIKHPDSDLPKGTINSILKQAGLK

Nucleotide

• Length: 183 bp

>T238582 NZ_LR890405:3315108-3315494 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14554.31 Da
• Isoelectric Point: 4.3652

>AT238582 WP_032829017.1 NZ_CP093428:250596-250997 [Pseudomonas migulae]
MKFPVVLHKDADSEYGVIIPDVPGCFSAGATVAQAFENVKEALSLHYEGLVADGDPLPQVQEIDAHIDNPDYAGGVWGVV
DFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Nucleotide

• Length: 402 bp

>AT238582 NZ_LR890405:3315484-3315813 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA