Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 88676..90299 Replicon plasmid pR18.0246_278k
Accession NZ_CP093412
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag MOP53_RS24240 Protein ID WP_000088046.1
Coordinates 88974..90299 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag MOP53_RS24235 Protein ID WP_024136327.1
Coordinates 88676..88969 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP53_RS25375 83746..83877 + 132 WP_000374059.1 hypothetical protein -
MOP53_RS24205 (MOP53_24205) 84218..84499 - 282 WP_000077926.1 hypothetical protein -
MOP53_RS24210 (MOP53_24210) 84549..84740 - 192 WP_000398480.1 hypothetical protein -
MOP53_RS24215 (MOP53_24215) 84964..86136 + 1173 WP_000952349.1 IS21-like element IS21 family transposase -
MOP53_RS24220 (MOP53_24220) 86136..86933 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
MOP53_RS24225 (MOP53_24225) 86972..87307 - 336 WP_065311125.1 hypothetical protein -
MOP53_RS24230 (MOP53_24230) 87680..88072 + 393 WP_000341066.1 hypothetical protein -
MOP53_RS24235 (MOP53_24235) 88676..88969 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
MOP53_RS24240 (MOP53_24240) 88974..90299 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
MOP53_RS24245 (MOP53_24245) 90360..90566 + 207 WP_000134171.1 hypothetical protein -
MOP53_RS24250 (MOP53_24250) 90668..91078 + 411 WP_000985911.1 hypothetical protein -
MOP53_RS24255 (MOP53_24255) 91091..91906 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
MOP53_RS24260 (MOP53_24260) 92160..92585 + 426 WP_001043843.1 hypothetical protein -
MOP53_RS24265 (MOP53_24265) 93134..93442 + 309 WP_001224687.1 hypothetical protein -
MOP53_RS24270 (MOP53_24270) 93458..94315 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
MOP53_RS24275 (MOP53_24275) 94377..94580 + 204 WP_001194555.1 hypothetical protein -
MOP53_RS24280 (MOP53_24280) 94922..95278 - 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / floR / aph(6)-Id / tet(A) / sul3 / lnu(F) / ant(3'')-Ia / sul2 / aac(3)-IId / blaLAP-2 / blaTEM-1B / blaCTX-M-55 / qnrS13 / ARR-3 / dfrA14 - 1..278374 278374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T238581 WP_000088046.1 NZ_CP093412:88974-90299 [Salmonella enterica subsp. enterica serovar Agona]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T238581 NZ_LR890405:3068072-3068566 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT238581 WP_024136327.1 NZ_CP093412:88676-88969 [Salmonella enterica subsp. enterica serovar Agona]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT238581 NZ_LR890405:3067782-3068075 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References