Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4136718..4138356 Replicon chromosome
Accession NZ_CP093411
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)


Gene name hipA Uniprot ID B5F4A8
Locus tag MOP53_RS20155 Protein ID WP_001255026.1
Coordinates 4136718..4138046 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B5F4A7
Locus tag MOP53_RS20160 Protein ID WP_001099274.1
Coordinates 4138051..4138356 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP53_RS20135 (4132256) 4132256..4133239 + 984 WP_000210270.1 toll/interleukin-1 receptor domain-containing protein -
MOP53_RS20140 (4133508) 4133508..4134035 - 528 WP_001043245.1 hypothetical protein -
MOP53_RS20145 (4134032) 4134032..4135228 - 1197 WP_000542997.1 hypothetical protein -
MOP53_RS20150 (4135417) 4135417..4136406 - 990 WP_077905772.1 restriction endonuclease -
MOP53_RS20155 (4136718) 4136718..4138046 - 1329 WP_001255026.1 type II toxin-antitoxin system HipA family toxin Toxin
MOP53_RS20160 (4138051) 4138051..4138356 - 306 WP_001099274.1 helix-turn-helix transcriptional regulator Antitoxin
MOP53_RS20165 (4139103) 4139103..4139573 + 471 WP_001222753.1 hypothetical protein -
MOP53_RS20175 (4141111) 4141111..4141347 + 237 WP_001748005.1 conjugal transfer protein TraG N-terminal domain-containing protein -
MOP53_RS20180 (4141464) 4141464..4142852 - 1389 WP_000121182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA7 - 4115598..4145829 30231


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-405)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50786.57 Da        Isoelectric Point: 5.0474

>T238576 WP_001255026.1 NZ_CP093411:c4138046-4136718 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

>T238576 NZ_LR890405:2211136-2211239 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11362.04 Da        Isoelectric Point: 9.7765

>AT238576 WP_001099274.1 NZ_CP093411:c4138356-4138051 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW

Download         Length: 306 bp

>AT238576 NZ_LR890405:c2211277-2211006 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4S6F6

Antitoxin

Source ID Structure
AlphaFold DB A0A3V5VUF2

References