Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 4136718..4138356 | Replicon | chromosome |
Accession | NZ_CP093411 | ||
Organism | Salmonella enterica subsp. enterica serovar Agona strain R18.0246 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | B5F4A8 |
Locus tag | MOP53_RS20155 | Protein ID | WP_001255026.1 |
Coordinates | 4136718..4138046 (-) | Length | 443 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | B5F4A7 |
Locus tag | MOP53_RS20160 | Protein ID | WP_001099274.1 |
Coordinates | 4138051..4138356 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MOP53_RS20135 (4132256) | 4132256..4133239 | + | 984 | WP_000210270.1 | toll/interleukin-1 receptor domain-containing protein | - |
MOP53_RS20140 (4133508) | 4133508..4134035 | - | 528 | WP_001043245.1 | hypothetical protein | - |
MOP53_RS20145 (4134032) | 4134032..4135228 | - | 1197 | WP_000542997.1 | hypothetical protein | - |
MOP53_RS20150 (4135417) | 4135417..4136406 | - | 990 | WP_077905772.1 | restriction endonuclease | - |
MOP53_RS20155 (4136718) | 4136718..4138046 | - | 1329 | WP_001255026.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
MOP53_RS20160 (4138051) | 4138051..4138356 | - | 306 | WP_001099274.1 | helix-turn-helix transcriptional regulator | Antitoxin |
MOP53_RS20165 (4139103) | 4139103..4139573 | + | 471 | WP_001222753.1 | hypothetical protein | - |
MOP53_RS20175 (4141111) | 4141111..4141347 | + | 237 | WP_001748005.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
MOP53_RS20180 (4141464) | 4141464..4142852 | - | 1389 | WP_000121182.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | fosA7 | - | 4115598..4145829 | 30231 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 443 a.a. Molecular weight: 50786.57 Da Isoelectric Point: 5.0474
>T238576 WP_001255026.1 NZ_CP093411:c4138046-4136718 [Salmonella enterica subsp. enterica serovar Agona]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLVEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDILSAWPVIGHGNNQISWQRCKLAMAVRGSSNYYHIYRVQRRHWINQGELNGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPSELAECIFEGMRQQCRRLAGRE
Download Length: 1329 bp
>T238576 NZ_LR890405:2211136-2211239 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 102 a.a. Molecular weight: 11362.04 Da Isoelectric Point: 9.7765
>AT238576 WP_001099274.1 NZ_CP093411:c4138356-4138051 [Salmonella enterica subsp. enterica serovar Agona]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW
Download Length: 306 bp
>AT238576 NZ_LR890405:c2211277-2211006 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3L4S6F6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V5VUF2 |